Development of multidisciplinary therapy based on mechanism of liver insufficiency in a use of Aged partial graft after liver transplantation.

基于肝功能不全机制的多学科治疗在肝移植术后使用老年部分移植物中的发展。

• 批准号: 23390324
• 负责人: SHIMADA Mitsuo
• 金额: $ 12.15万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390324/
• 关键词: 肝不全; 加齢肝; 幹細胞; 加齢遺伝子; マイクロダイアライシス

The majority of liver transplantation in Japan is living donor liver transplantation. As aging population has recently been increasing, aged liver of a donor candidate has become a most problem. We gave similar surgical insults as liver transplantation, including ischemia-reperfusion injury and massive hepatectomy in the aged liver. We obtained several novel findings regarding the mechanisms, by which aging induced liver functional and regenerative insufficiency. We also found some possible therapeutic agents and strategies including ADRC, HDAC inhibitor and the others, which may improve the liver dysfunction and may support liver regeneration in these animal models.

日本的肝移植大部分是活体肝移植。近年来，随着人口老龄化的加剧，供体候选者的肝脏老化已成为最大的问题。我们进行了与肝移植类似的手术损伤，包括缺血再灌注损伤和对老化肝脏进行大规模肝切除。我们获得了一些关于衰老导致肝功能和再生功能不全的机制的新发现。我们还发现了一些可能的治疗药物和策略，包括 ADRC、HDAC 抑制剂等，可以改善这些动物模型的肝功能障碍并支持肝再生。

项目成果

Beneficial Effects of Follistatin in Hepatic Ischemia-Reperfusion Injuries in Rats

• DOI: 10.1007/s10620-010-1401-4
• 发表时间: 2011-04-01
• 期刊: DIGESTIVE DISEASES AND SCIENCES
• 影响因子: 3.1
• 作者: Kanamoto, Mami;Shimada, Mitsuo;Arakawa, Yusuke
• 通讯作者: Arakawa, Yusuke

Recovery pattern of non-protein respiratory quotient and non-esterified fatty acids after liver resection

肝切除术后非蛋白质呼吸商和非酯化脂肪酸的恢复模式

• DOI: 10.1016/j.nut.2013.09.012
• 发表时间: 2014
• 期刊: Nutrition
• 影响因子: 4.4
• 作者: Sugihara K;Yamanaka-Okumura H;Teramoto A;Urano E;Katayama T;Mori H;Utsunomiya T;Shimada M;Takeda E
• 通讯作者: Takeda E

The gene profile in the spleen under rat small-for-size graft model using cDNA microarray and pathway analaysis

使用 cDNA 微阵列和通路分析研究大鼠小型移植模型下脾脏的基因谱

• 发表时间: 2013
• 作者: Arakawa Y ;Shimada M;Ishikawa D;Y amada S;Saito Y ;T akasu C;Iwahashi S;Kanamoto M;Mori H;Ikemoto T ;Morine Y ;Imura S;Utsunomiya T ;Sato H;Miyake H
• 通讯作者: Miyake H

Whey protein isolate, MEIN[〇!R], can reduce liver damege early after living donor liver transplantation

乳清分离蛋白 MEIN[〇!R] 可减少活体肝移植后早期的肝损伤

• 发表时间: 2011
• 作者: Ishikawa D;Shimada M;Utsunomiya T;Imura S;Morine Y;Ikemoto T;Mori H;Hanaoka J;Kanamoto M;Iwahashi S;Saito Y ;Asanoma M;Kume H;Sasaki H
• 通讯作者: Sasaki H

Impact of human adipose tissue derived regenerative cell for cryopreserved porcine islets

人脂肪组织来源的再生细胞对冻存猪胰岛的影响

• 发表时间: 2012
• 作者: Ikemoto T;Shimada M;Utsunomiya T;Imura S;Morine Y;Hanaoka J;Miyatani T ;Kanamoto M
• 通讯作者: Kanamoto M