Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods

阐明肠道免疫细胞对微生物的识别和反应与免疫调节功能食品的开发相关

• 批准号: 23380073
• 负责人: HACHIMURA SATOSHI
• 金额: $ 11.98万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23380073/
• 关键词: 腸管免疫系; 腸内共生菌; 機能性食品; IgA抗体; TLR; 制御性T細胞; 樹状細胞; 経口免疫寛容; 制御性Ｔ細胞; 感染防御

In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.

在这项研究中，我们试图阐明肠道免疫细胞的功能，重点关注它们对微生物和微生物成分的反应，与新型免疫调节功能食品的开发相关。我们检查了派尔斑树突状细胞对多重 TLR 模拟的抑制反应。我们分析了 CD3-IL-2R+ 细胞，发现它们也存在于肺部，并且它们对流感病毒感染有反应。我们还检测了口服耐受诱导的调节性 T 细胞的基因表达。此外，我们还研究了拟杆菌诱导 IgA 的机制。

项目成果

Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice.

与年轻小鼠相比，老年小鼠 CD4 T 细胞迁移特性的减弱与趋化因子受体表达、对视黄酸的反应和 RALDH 表达的降低相关。

• DOI: 10.1080/09168451.2014.910099
• 发表时间: 2014
• 期刊: Biosci. Biotechnol. Biochem.
• 作者: Jihyun Park;Takuya Miyakawa;Aya Shiokawa;Haruyo Nakajima-Adachi;Masaru Tanokura;Satoshi Hachimura
• 通讯作者: Satoshi Hachimura

Commensal bacteria promote migration of mast cells into the intestine

• DOI: 10.1016/j.imbio.2010.10.007
• 发表时间: 2011-06-01
• 期刊: IMMUNOBIOLOGY
• 影响因子: 2.8
• 作者: Kunii, Junichi;Takahashi, Kyoko;Kaminogawa, Shuichi
• 通讯作者: Kaminogawa, Shuichi

Generation of memory B cells inside and outside germinal centers

• DOI: 10.1002/eji.201343716
• 发表时间: 2014-05-01
• 期刊: EUROPEAN JOURNAL OF IMMUNOLOGY
• 影响因子: 5.4
• 作者: Takemori, Toshitada;Kaji, Tomohiro;Rajewsky, Klaus
• 通讯作者: Rajewsky, Klaus

Gut as a target for functional food

• DOI: 10.1016/j.tifs.2011.06.002
• 发表时间: 2011-12-01
• 期刊: TRENDS IN FOOD SCIENCE & TECHNOLOGY
• 影响因子: 15.3
• 作者: Shimizu, Makoto;Hachimura, Satoshi
• 通讯作者: Hachimura, Satoshi

加齢による免疫機能変化と食品による調節

衰老引起的免疫功能变化和食物的调节

• 发表时间: 2014
• 作者: 八村敏志;田之倉優
• 通讯作者: 田之倉優