Development of research with liposomes toward clinical application for cancer and AIDS

脂质体在癌症和艾滋病临床应用方面的研究进展

• 批准号: 23300173
• 负责人: MATSUMOTO Yoko
• 金额: $ 11.48万
• 依托单位: Sojo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23300173/
• 关键词: 癌; リポソーム; エイズ; アポトーシス; 担がんマウス; トレハロース; シグナル伝達; トランスレーショナルリサーチ; 脂質; 細胞・組織

We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We investigated the anticancer and anti-AIDS effects of HL and following results are obtained. (A) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (B) apoptotic induction pathway which targeted tumor cell membranes was observed. (C) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL in vivo. Long-term selective accumulation of fluorescent labeled HL-25 into tumor was observed in pharmacokinetics test using mice model of carcinoma. (D) therapetutic effects of treatment for the lymphoma with relation to AIDS was obtained. These findings suggest that HL should be a new type of nanomedicinaldrug anti-cancer and anti-AIDS that targets refractory disease cell-membranes to trigger apoptotic cell death for various cancer cells.

我们已经产生了杂化脂质体（HL），可以通过缓冲溶液中的水泡和胶束分子超声处理。我们研究了HL的抗癌和抗AID效应，并获得了以下结果。 （a）在体外获得了HL对各种肿瘤细胞生长的显着抑制作用。 （b）观察到靶向肿瘤细胞膜的凋亡诱导途径。 （c）用HL体内治疗后使用小鼠癌模型获得了明显的化学治疗作用。在药代动力学测试中，使用癌模型在药代动力学测试中观察到了将荧光标记为HL-25的长期选择性积累。 （d）获得与艾滋病有关的淋巴瘤治疗的治疗作用。这些发现表明，HL应该是一种新型的纳米杂型抗癌药物和抗ASAID，靶向难治性疾病细胞膜，以触发各种癌细胞的凋亡细胞死亡。

项目成果

New Cancer Immunotherapy Using Autologous Lymphocytes Activated with Trastuzumab

• DOI: 10.1248/bpb.b12-00378
• 发表时间: 2012-08-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Nakagawa, Shinichirou;Matsuoka, Yusuke;Ueoka, Ryuichi
• 通讯作者: Ueoka, Ryuichi

Anti-tumor effects of Cationic hybrid liposomes Against colon carcinoma along with apoptosis

阳离子杂化脂质体抗结肠癌及细胞凋亡的抗肿瘤作用

• 发表时间: 2012
• 作者: 亀井 謙一郎;劉 莉;吉岡 桃子;長谷川 光一;中辻 憲夫;陳 勇;日野 元貴
• 通讯作者: 日野 元貴

ハイブリッドリポソームの肺がん細胞に対する細胞周期停止およびアポトーシス誘導によるがん抑制機構

混合脂质体通过细胞周期阻滞和凋亡诱导对肺癌细胞的抑癌机制

• 发表时间: 2013
• 作者: 古水雄志;松本陽子;上岡龍一
• 通讯作者: 上岡龍一

Membrane-targeted therapy with hybrid liposomes in Relation to fluctuation and apoptosis

混合脂质体膜靶向治疗与波动和细胞凋亡的关系

• 发表时间: 2012
• 作者: Nakamura M;Kobayashi A;Nozaki K;Horiuchi N;Nagai A;Yamashita K;Kenichi Hatanaka;Y. Matsumoto
• 通讯作者: Y. Matsumoto

Chemotherapy with hybrid liposomes for cancer model mice leading to apoptosis in VIVO

VIVO 癌症模型小鼠混合脂质体化疗导致细胞凋亡

• 发表时间: 2012
• 作者: Takatori Y;Moro T;Kamogawa M;Oda H;Morimoto S;Umeyama T;Minami M;Sugimoto H;Nakamura S;Karita T;Kim J;Koyama Y;Ito H;Kawaguchi H;and Nakamura K;Hideaki Ichihara
• 通讯作者: Hideaki Ichihara