Study of novel lipid-lowering effects of sesaminol, a sesame lignan

芝麻木脂素芝麻素酚的新型降脂作用研究

• 批准号: 22700752
• 负责人: NISHIZONO Shoko
• 金额: $ 2.58万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700752/
• 关键词: ゴマリグナン; セサミノールアグリコン; 脂質代謝; ラット; 栄養学; 食品; 脂質; 植物; 農林水産品; 脂質代謝調節; セサミノール; トリグリセリド濃度; コレステロール濃度

Sesaminol is a sesame lignin and is present most exclusively occurring as sesaminol triglucoside in sesame seed. In this study, effect of sesaminol aglycone on lipid metabolism was investigated in Sprague-Dawley rats. Four-week-old male rats were fed diets containing 0～ 0. 20% sesaminol. After 4 week-feeding period, serum and liver lipids levels were determined. We reported, for the first time, that dietary sesaminol significantly reduce(s) serum and hepatic lipids, especially triglyceride levels in a dose dependent manner ; this reduction appeared to be greater than those of a well-known other functional components. The mechanism responsible for the observed reduction in the concentration of triglyceride may be due to a reciprocal response in the enzyme activities involved in fatty acid synthesis and oxidation.

芝麻醇是在芝麻中最不受欢迎的triglucoside，其中一种在脂质代谢上。确定血清和肝脏水平。 RES在酶活性中的反应中的反应相关涉及相关综合和氧化。