Elucidation of effect of lipid signaling on cross talk between synapses

阐明脂质信号传导对突触之间串扰的影响

• 批准号: 22700362
• 负责人: UEDA Yoshibumi
• 金额: $ 2.5万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700362/
• 关键词: ホスファチジルイノシトール3, 4, 5-三リン酸; PIP_3; 蛍光寿命; 蛍光共鳴エネルギー移動; シナプス可塑性; スパイン; ホスファチジルイノシトール三リン酸; シナプス構造可塑性; 2光子顕微鏡; FLIM; PIP3; PTEN; Cagedグルタミン酸

Activity input to spines changes its morphology such as the size and shape related to structural plasticity, contributing to acquire long-term potentiation(LTP) underling learning and memory. However what kind of factor regulates the change in the morphology remains. We found that the number of the spinule and the degree of PIP_3 accumulation in spinules increased in a PIP_3-concentration dependent manner. Spinules accumulating PIP_3 may be sent to presynaptic side through trans-endocytosis proposed in electromicroscopy study, resulting in strengthen synapse connectivity.

脊柱的活动输入会改变其形态，例如与结构可塑性相关的大小和形状，有助于获得学习和记忆的长时程增强（LTP）。然而什么样的因素调节形态的变化仍然存在。我们发现小刺的数量和小刺中 PIP_3 积累的程度以 PIP_3 浓度依赖性方式增加。积累PIP_3的小刺可能通过电显微镜研究中提出的反式内吞作用被发送到突触前侧，从而增强突触连接。