Telencephalin binds to vitronectin and regulates synapse formation

端脑素与玻连蛋白结合并调节突触形成

• 批准号: 22700354
• 负责人: FURUTANI Yutaka
• 金额: $ 2.66万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700354/
• 关键词: テレンセファリン; ビトロネクチン; スパイン; シナプス形成; 細胞接着分子; 細胞外マトリックス; 樹状突起フィロポディア; シナプス; プロテオミクス

I report the identification of telencephalin as a novel vitronectin receptor on neuronal dendrites. Vitronectin-coated microbeads induce the accumulation of telencephalin and the formation of phagocytic cup-like plasma membrane protrusions on dendrites of cultured hippocampal neurons. Vitronectin-deficient mice displays marked enlargement of spine heads in hippocampal CA1 pyramidal neurons. These results suggest that the vitronectin and its neuronal receptor telencephalin play a pivotal role in spine morphogenesis.

我报告了尾脑蛋白是神经元树突上的新型玻璃体受体的鉴定。玻染素涂层的微珠诱导尾脑蛋白的积累，并在培养的海马神经元的树突上形成吞噬杯状质膜突起。缺乏蛋白的小鼠在海马CA1锥体神经元中显示出明显的脊柱头部扩大。这些结果表明，玻染蛋白及其神经元受体尾脑在脊柱形态发生中起关键作用。

项目成果

Identification and characterization of nCLP2, a novel C1q family protein expressed in the central nervous system

• DOI: 10.1093/jb/mvp203
• 发表时间: 2010-04-01
• 期刊: JOURNAL OF BIOCHEMISTRY
• 影响因子: 2.7
• 作者: Shimono, Chisei;Manabe, Ri-ichiroh;Sekiguchi, Kiyotoshi
• 通讯作者: Sekiguchi, Kiyotoshi

Small GTPase Rab17 Regulates Dendritic Morphogenesis and Postsynaptic Development of Hippocampal Neurons

• DOI: 10.1074/jbc.m111.314385
• 发表时间: 2012-03-16
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Mori, Yasunori;Matsui, Takahide;Fukuda, Mitsunori
• 通讯作者: Fukuda, Mitsunori

An extracellular transglutaminase is required for apple pollen tube growth

• DOI: 10.1042/bj20100291
• 发表时间: 2010-07-15
• 期刊: BIOCHEMICAL JOURNAL
• 影响因子: 4.1
• 作者: Di Sandro, Alessia;Del Duca, Stefano;Serafini-Fracassini, Donatella
• 通讯作者: Serafini-Fracassini, Donatella

Proteomic Analysis of Dendritic Filopodia

树突丝状伪足的蛋白质组学分析

• 发表时间: 2014
• 作者: Furutani;Y.;Kawasaki;M.;Matsuno;H.;Mitsui;S.;Mori;K. and Yoshihara;Y.;古谷 裕;Yutaka Furutani and Yoshihiro Yoshihara
• 通讯作者: Yutaka Furutani and Yoshihiro Yoshihara

Vitronectin Binds to Telencephalin and Regulates Dendritic Spine Morphologenesis

玻连蛋白与端脑素结合并调节树突棘形态发生

• 发表时间: 2011
• 作者: Y. Furutani;M. Kawasaki;H. Matsuno;S. Mitusi;K. Mori;Y. Yoshihara
• 通讯作者: Y. Yoshihara