roles of serotonin in the body axis formation

血清素在身体轴形成中的作用

• 批准号: 22687016
• 负责人: MAEGAWA Shingo
• 金额: $ 13.06万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22687016/
• 关键词: 形成体; セロトニン; オーガナイザー; 形態形成; 胚発生

Serotonin is a well-known neurotransmitter involved in sociality and/or behavior of animal. In the present study, we revealed that Tphd2, a serotonin synthesis emzyme, is expressed in the organizer in zebrafish. In addition, serotonin itself is expressed during gastrulation depending on the organizer. Inhibition of Tphd2 by antisense resulted in shortened body axis. Molecular and developmental studies demonstrated that Thpd2 is required for migration of cells toward to the dorsal region during morphogenesis. Finally, the results clearly indicate that serotonin is involved in early body patterning in zebrafish development.

5-羟色胺是涉及社会性和/或动物行为的著名神经递质。在本研究中，我们透露TPHD2是一种5-羟色胺合成胚泡，在斑马鱼的组织者中表达。此外，在胃酸期间根据组织者表达了5-羟色胺本身。反义对TPHD2的抑制导致体轴缩短。分子和发育研究表明，在形态发生过程中，细胞向背区域迁移到背区域是必需的。最后，结果清楚地表明5-羟色胺参与斑马鱼发育中的早期身体形成。

项目成果

Induction and patterning of trunk and tail neural ectoderm by the homeobox gene eve1 in zebrafish embryos

• DOI: 10.1073/pnas.1000389107
• 发表时间: 2010-02-23
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Cruz, Carlos;Maegawa, Shingo;Kudoh, Tetsuhiro
• 通讯作者: Kudoh, Tetsuhiro

Visualization of serotonergic neurons in living zebrafish

活体斑马鱼血清素能神经元的可视化

• 发表时间: 2010
• 作者: Shunji Fujioka;et al
• 通讯作者: et al

Serotonin is involved in embryogenesis in zebrafish

血清素参与斑马鱼的胚胎发生

• 发表时间: 2010
• 作者: Yudai Tokumasu;et al
• 通讯作者: et al