Functional Connectivity Across Cortical Regions in Schizophrenia

精神分裂症皮质区域的功能连接

• 批准号: 22659210
• 负责人: HASHIMOTO Takanori
• 金额: $ 2.05万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659210/
• 关键词: 脳波; 脳磁図; 認知機能; 統合失調症; オシレーション; 陽性症状; 陰性症状; 解体症状; 脳波; 脳磁図; 認知機能; 統合失調症; オシレーション; 陽性症状; 陰性症状; 解体症状

Functional connectivities among cerebral cortical areas wereassessed by electroencephalography and magnetoencephalography in patients with schizophrenia. Drug-naive and first-episode patients exhibited reduced synchronizations of neural activities across global cortical areas. This reduction was most prominent betweenfrontal regions and other cortical areas. Amelioration of symptoms by antipsychotics was positively correlated with the improvement of the global synchronizations. Chronic patients, after the long-term treatments, showed increased coherences among cortical areas. Antipsychotic treatment appeared to have an effect to enhance the cortical synchronization.

精神分裂症患者的脑脑摄影和磁脑摄影的脑皮质区域之间的功能连接性。药物症和第一集患者表现出在全球皮质区域的神经活动同步降低。这种降低是边区和其他皮质区域之间最突出的。通过抗精神病药改善症状与全球同步的改善呈正相关。长期治疗后，慢性患者在皮质区域之间表现出增加的相干性。抗精神病药物似乎具有增强皮质同步的作用。