Research of tumor development due to failure in cell competition

细胞竞争失败导致肿瘤发生的研究

• 批准号: 22657033
• 负责人: NAKANISHI Yoshinobu
• 金额: $ 2.07万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22657033/
• 关键词: 細胞競合; 発癌; ショウジョウバエ; 発生; 細胞貪食; アポトーシス; 紬胞競合; 細胞貧食; 細胞競合; 発癌; ショウジョウバエ; 発生; 細胞貪食; アポトーシス; 紬胞競合; 細胞貧食

We generated a Drosophila line that lacks receptors responsible for the phagocytic removal of apoptotic cells. These flies had prolonged larval stage, indicating the importance of apoptotic cell clearance in growth. To determine the characteristic of' loser cells', which remain in animals due to a defect in phagocytosis, a mosaic mutation for artificial cell competition was introduced into a phagocytosis-deficient fly line. However, we could not complete the examination of these flies within the allocated research period.

我们产生了一条果蝇线，该系缺乏负责吞噬细胞吞噬细胞的受体。这些苍蝇延长了幼虫阶段，表明凋亡细胞清除率在生长中的重要性。为了确定由于吞噬作用缺陷而保留在动物中的“失败者细胞”的特征，将用于人造细胞竞争的镶嵌性突变引入了缺陷型缺陷的蝇线中。但是，我们无法在分配的研究期内完成对这些苍蝇的检查。