Study of insulin resistance on oral mucosa disease and hepatitis C? role of a dentist

胰岛素抵抗对口腔粘膜疾病和丙型肝炎的影响研究？

• 批准号: 22592354
• 负责人: NAGAO Yumiko
• 金额: $ 2.91万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592354/
• 关键词: 口腔粘膜疾患; 扁平苔癬; 肝外病変; C型肝炎ウイルス; インターフェロン; イ ンスリン抵抗性; 歯学; 分岐鎖アミノ酸; 口腔扁平苔癬; ウイルス変異; C型肝炎; 口腔カンジダ症; 歯科医師; オーラルメディシン; アルブミン; 低アルブミン血症; インスリン抵抗性

In Japan, there are over two million hepatitis C virus (HCV) infected people. HCV infection is the nation's largest infection. On the other hand, HCV causes various kinds of extrahepatic manifestations as well as liver diseases. Oral lichen planus (OLP), Sjogren's syndrome are the representative diseases of extrahepatic manifestations. It was found that an insulin resistance that HCV infection caused was associatedwith not only oralcancerbut alsothemultipleprimaryneoplasm.Furthermore, we clarified follows: (1) Dental problems delaying the initiation of interferon (IFN) therapy for HCV-infected patients, (2) branched-chain amino acids (BCAA)-enriched supplementincludingzincimprovesthesensitivitytotasteinpatientswith HCV-infected liver disease, (3) Candidiasis and other oral mucosal lesions during and after IFN therapy for HCV-related chronic liver diseases, (4) A retrospective case-control study of HCV infection and OLP in Japan: association study with mutations in the core and N5A region of HCV.

在日本，有超过200万丙型肝炎病毒（HCV）感染的人。 HCV感染是美国最大的感染。另一方面，HCV引起各种肝外表现以及肝病。口腔地衣披体（OLP），Sjogren综合征是肝外表现的代表性疾病。发现HCV感染引起的一种胰岛素耐药性不仅与口腔抗体，但我们澄清了：（1）牙齿问题延迟了Interferon（IFN）治疗HCV感染患者（IFN）治疗的牙科问题， supplementincludingzincimprovesthesensitivitytotasteinpatientswith HCV-infected liver disease, (3) Candidiasis and other oral mucosal lesions during and after IFN therapy for HCV-related chronic liver diseases, (4) A retrospective case-control study of HCV infection and OLP in Japan: association study with mutations in the core and N5A region of HCV.

项目成果

Effect of branched-chain amino acid-enriched nutritional supplementation on interferon therapy in Japanese patients with chronic hepatitis C virus infection: a retrospective study.

• DOI: 10.1186/1743-422x-9-282
• 发表时间: 2012-11-22
• 期刊: Virology journal
• 影响因子: 4.8
• 作者: Nagao Y;Kawaguchi T;Ide T;Sata M
• 通讯作者: Sata M

Serum albumin and mortality risk in a hyperendemic area of HCV infection in Japan.

• DOI: 10.1186/1743-422x-7-375
• 发表时间: 2010-12-31
• 期刊: Virology journal
• 影响因子: 4.8
• 作者: Nagao Y;Sata M
• 通讯作者: Sata M

Cohort研究からみたウイルス性肝炎の解明 九州X町住民のコホート研究から得られた知見と解決策

从队列研究的角度阐释病毒性肝炎：九州X镇居民队列研究的认识与解答

• 发表时间: 2012
• 作者: 長尾由実子;佐田通夫
• 通讯作者: 佐田通夫

肝疾患の進展予防と患者教育に向けたiPaアプリの開発

开发用于预防肝病进展和患者教育的 iPa 应用程序

• 发表时间: 2012
• 期刊: 医療情報誌シュネラー
• 作者: Moriya Shingo;Tei Kanchu;長尾由実子
• 通讯作者: 長尾由実子

Plasma active ghrelin level was depleted and associated with serum albumin level in HCV-infected patients

HCV 感染患者血浆活性生长素释放肽水平降低并与血清白蛋白水平相关

• 发表时间: 2012
• 作者: Kawaguchi T;Nagao Y;Sata M
• 通讯作者: Sata M