Development of novel endothelial keratoplasty (nDSAEK) for bullous keratopathy and its visual function analysis

新型内皮角膜移植术（nDSAEK）治疗大疱性角膜病的发展及其视功能分析

• 批准号: 22591934
• 负责人: KOBAYASHI Akira
• 金额: $ 2.91万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591934/
• 关键词: 角膜移植; 角膜内皮移植; 角膜内皮移植術; DSAEK; nDSAEK; 共焦点顕微鏡; 水疱性角膜症

According to a research project, we conducted a research to compare the clinical results after DSAEK(Descemet stripping automated endothelial keratoplasty)and nDSAEK(non-Descemet stripping automated endothelial keratoplasty). As a result, no statistical difference was observed between these two groups in terms of the visual acuity, and best corrected visual acuity, endothelial cell density. Also, no differencewas observed for donor adherence rate. In vivo laser confocal microscopy revealed that subepithelial opacity, stromal needle shaped bodies, donor recipient interface opacity and particles. Most notably, giant hyperreflective materials were observed at donor recipient interface only in nDSAEK group; these were considered to be necrotic and aggregated host endothelial cells and seemed to have no side effect to postoperative visual acuity.

根据一项研究项目，我们进行了一项研究，比较DSAEK（后弹力层剥离自动化内皮角膜移植术）和nDSAEK（非后弹力层剥离自动化内皮角膜移植术）后的临床结果。结果，两组之间在视力、最佳矫正视力、内皮细胞密度方面没有观察到统计学差异。此外，捐赠者依从率也没有观察到差异。体内激光共聚焦显微镜显示上皮下混浊、基质针状体、供受体界面混浊和颗粒。最值得注意的是，仅在 nDSAEK 组中，在供体受体界面处观察到巨大的超反射材料；这些被认为是坏死和聚集的宿主内皮细胞，并且似乎对术后视力没有副作用。

项目成果

角膜内皮移植術（DSAEK/DMEK）の現在と今後の展望

内皮性角膜移植（DSAEK/DMEK）的现状及未来展望

• 作者: Kobayashi A;Yokogawa H;Sugiyama K.;小林顕;小林顕;小林顕
• 通讯作者: 小林顕

角膜内皮移植術(DSAEK)の臨床と最近の話題

内皮角膜移植 (DSAEK) 的临床和最新主题

• 发表时间: 2012
• 作者: Yokogawa H;Kobayashi A;Tagawa K;Sugiyama K.;小林 顕
• 通讯作者: 小林 顕

Descemet Stripping Automated Endothelial Keratoplasty for Microcornea

小角膜后弹力层剥离自动内皮角膜移植术

• DOI: 10.1007/s10384-012-0163-2
• 发表时间: 2012
• 期刊: Jpn J Ophthalmol
• 影响因子: 2.4
• 作者: Toshida H;Ohta T;Murakami A;Kobayashi A;Sugiyama K
• 通讯作者: Sugiyama K

Clinical Outcomes With the Tan End Glide : A New Donor Inserter for DSAEK

Tan End Glide 的临床结果：用于 DSAEK 的新型供体插入器

• 发表时间: 2010
• 作者: Yokogawa H;Kobayashi A;Sugiyama K.
• 通讯作者: Sugiyama K.

Intraocular Pressureping Automated After Descemet Stripping and Non-Descemet Strip Endothelial Keratoplasty

后弹力层剥离和非后弹力层剥离内皮角膜移植术后自动眼内压

• 发表时间: 2010
• 作者: Mawatari Y;Kobayashi A;Yokogawa H;Sugiyama K
• 通讯作者: Sugiyama K