The stress reaction and therapy for irritable bowel syndrome

肠易激综合征的应激反应及治疗

• 批准号: 22790609
• 负责人: MORISHITA Joe
• 金额: $ 2.83万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790609/
• 关键词: 過敏性腸症候群; 脳機能画像; 脳腸相関; 消化管運動機能; 拡散テンソル画像; ストレス; 消化管運動

There is no specific emotional task for patients with irritable bowel syndrome. Authors made the original task which provokes negative emotion in patients with irritable bowel syndrome. Irritable bowel syndrome-related pictures were presented to healthy controls and patients with irritable bowel syndrome. Healthy controls showed no changes in emotion, while patients with irritable bowel syndrome showed increase in negative emotion. Moreover, abdominal pain and urgency of defecation were exaggerated. This task is applicable for functional magnetic resonance imaging. In Voxel-based morphometry analysis, patients with irritable bowel syndrome showed significant increase of signal at premotor area and supplementary motor area. And in Diffusion tensor Imaging analysis, the area(38, -46, -2) represented significant increase of signal in patients with irritable bowel syndrome.

肠易激综合症患者没有具体的情感任务。作者做了最初的任务，这会激发肠易激综合症患者的负面情绪。肠易激综合征相关的图片呈现给健康对照和肠易激综合征的患者。健康对照没有表现出情绪的变化，而肠易激综合症患者则表现出负面情绪的增加。此外，腹部疼痛和排便的紧迫性被夸大了。此任务适用于功能磁共振成像。 在基于体素的形态计算分析中，肠易激综合征患者在前运动区域和补充运动区域的信号显着增加。在扩散张量成像分析中，该区域（38，-46，-2）代表肠易激综合征患者的信号显着增加。

项目成果

Clomipramine reduces visceral perception-related brain activation in humans

氯米帕明减少人类内脏知觉相关的大脑激活

• 发表时间: 2011
• 作者: Fukudo S;et al
• 通讯作者: et al

Brain histamine H1 receptor binding in patients with diarrhea dominant irritable bowel syndrome

腹泻显性肠易激综合征患者脑组织胺 H1 受体结合

• 发表时间: 2013
• 作者: Sekiguchi A;Sugiura M;Yokoyama S;Sassa Y;Horie K;Sato S;Kawashima R.;Uemura Y.;森下 城
• 通讯作者: 森下 城

Corticotropin-releasing hormone exaggerates regional brain activity and adrenocorticotropic hormone and cortisol release during colorectal distention in men

促肾上腺皮质激素释放激素会加剧男性结直肠扩张期间的区域大脑活动以及促肾上腺皮质激素和皮质醇的释放

• 发表时间: 2011
• 作者: Yukari Tanaka;Joe Morishita;Motoyori kanazawa,Toyohiro Hamaguchi;Manabu Tashiro;Shin Fukudo
• 通讯作者: Shin Fukudo

Neural characteristics of cognitive control of negative emotion in subjects with irritable bowel syndrome

肠易激综合征受试者负性情绪认知控制的神经特征

• 作者: Sekiguchi A;Sugiura M;Morishita J;Kotozaki Y;Aizawa E;Fukudo S;Kawashima R
• 通讯作者: Kawashima R

Neural substrates of decision making in irritable bowel syndrome

肠易激综合征决策的神经基础

• 发表时间: 2011
• 作者: Aizawa E;Kanazawa M;et al
• 通讯作者: et al