Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rat

阿朴吗啡诱导的大鼠腹外侧纹状体神经活动的调节

• 批准号: 22792127
• 负责人: MIZOGUCHI Naoko
• 金额: $ 2.5万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792127/
• 关键词: 摂食嚥下障害; パーキンソン病; オーラルジスキネジア; 大脳基底核; ドパミン神経系; マルチ・チャネル・ユニット法

The dopaminergic system in the ventrolateral portion of striatum(Svl), a part of basal ganglia, plays an important role in the regulation of orofacial movements : bilateral co-stimulation of both dopamine D1-like and D2-like receptors elicits repetitive jaw movements in rats. However, it is still unknown how activities of Svl neurons are modulated by activation of dopaminergic receptors. In the present study, we systematically injected apomorphine(2 mg/kg i. v.), a non-selective dopamine receptor agonist, that induced jaw movements under urethane anesthesia, and performed multi-channel unit recording from Svl neurons. According to the spike firing patterns, the Svl neurons were classified into two subtypes ; phasically active(PA) and tonically active(TA) neurons. The divergent effects of apomorphine on PA neurons in the Svl might reflect differential expression of D1-like and D2-like receptors in the middle spiny neurons. Apomorphine-induced suppression of TA neuron activities with decreased synchronized outputs is likely to reduce locally released acetylcholine, which may modulate apomorphine-induced jaw movements.

纹状体（SVL）（基底神经节的一部分）的腹侧部分中的多巴胺能系统在调节口径运动中起着重要作用：双侧D1-D1样受体和D2样受体的双边共同刺激引起大鼠重复的JAW运动。但是，仍然未知SVL神经元的活性如何通过多巴胺能受体的激活调节。在本研究中，我们系统地注射了一种非选择性的多巴胺受体激动剂（2 mg/kgi。v。），在尿烷麻醉下诱导颌骨运动，并从SVL NEURONS进行多通道单位记录。根据尖峰射击模式，将SVL神经元分为两个亚型。定位（PA）和音调（TA）神经元。 Apomorphine对SVL中PA神经元的发散作用可能反映了中间棘神经元中D1样和D2样受体的差异表达。磷灰碱诱导的抑制具有同步输出降低的TA神经元活性可能会减少局部释放的乙酰胆碱，这可能会调节磷灰碱诱导的颌骨运动。

项目成果

社会福祉施設での摂食・嚥下障害に対する2年間の取り組み

社会福利机构两年来努力治疗饮食和吞咽障碍

• 发表时间: 2010
• 作者: 阿部仁子;溝口尚子;田尻陽子;飯田貴俊;戸原玄;植田耕一郎;市村志乃;斉藤朋子;米山佳代子
• 通讯作者: 米山佳代子

Spatiotemporal dynamics of long-term potentiation in rat insular cortex revealed by optical imaging

• DOI: 10.1016/j.nlm.2011.07.003
• 发表时间: 2011-10-01
• 期刊: NEUROBIOLOGY OF LEARNING AND MEMORY
• 影响因子: 2.7
• 作者: Mizoguchi, Naoko;Fujita, Satoshi;Kobayashi, Masayuki
• 通讯作者: Kobayashi, Masayuki

Spatiotemporal profiles of long-term potentiation in rat insular cortex : an optical imaging study

大鼠岛叶皮质长时程增强的时空分布：光学成像研究

• 发表时间: 2011
• 作者: Takei H;Fujita S;Shirakawa T;Koshikawa N;Kobayashi M;Mizoguchi N
• 通讯作者: Mizoguchi N

SPATIOTEMPORAL PROFILES OF TRANSCALLOSAL CONNECTIONS IN RAT INSULAR CORTEX REVEALED BY IN VIVO OPTICAL IMAGING

• DOI: 10.1016/j.neuroscience.2012.01.014
• 发表时间: 2012-03-29
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Fujita, S.;Kitayama, T.;Kobayashi, M.
• 通讯作者: Kobayashi, M.

Apomorphineの線条体腹外側部ニューロンの活動に対する修飾作用

阿朴吗啡对腹外侧纹状体神经元活性的调节作用

• 发表时间: 2011
• 作者: Takei H;Fujita S;Shirakawa T;Koshikawa N;Kobayashi M;Mizoguchi N;武井浩樹;納谷はるな
• 通讯作者: 納谷はるな