Cleft palate and filopodia the influence of inositol will prevent cleft palate-

腭裂和丝状伪足 肌醇的影响将预防腭裂-

• 批准号: 22792028
• 负责人: FUJIWARA Kumiko
• 金额: $ 1.66万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792028/
• 关键词: 口蓋裂; イノシトール; 予防; Filopodia; アクチン線維; 口唇口蓋裂; AJ系マウス; ICR系マウス; フィロポディア

A/J mouse witch is the spontaneous CLP strain was used and the inositol medication group and the control group considered incidence of CLP. By the inositol group, the unilateral cleft lip and palate(UCLP) was not accepted at all, but a bilateral cleft lip and palate(BCLP) accepted the control tendency as compared with the control. In morphologic observation, the systemic influence on the pregnant body or an embryo was not accepted. It has an effect which controls BCLP considered that the obstacle of inositol is serious. Furthermore, it was thought that inositol was useful as a prevention method of CLP since there is nothing influence for pregnant women and embryo.

A/J小鼠是自发性CLP品系，肌醇药物组和对照组考虑CLP的发生率。与对照组相比，肌醇组完全不接受单侧唇腭裂（UCLP），但双侧唇腭裂（BCLP）接受对照倾向。在形态学观察中，不接受对妊娠身体或胚胎的全身影响。认为肌醇的障碍严重，具有抑制BCLP的效果。此外，肌醇对孕妇和胚胎没有影响，因此被认为作为CLP的预防方法是有用的。

项目成果

顎裂部に歯胚を含む腫瘤を認めた1症例

颌裂区含牙胚肿块一例

• 发表时间: 2010
• 作者: 菅原由紀;他;加藤大貴;藤原久美子
• 通讯作者: 藤原久美子