Differentiation induction of mesenchymal stem cells in the peripheral blood into tooth structure forming cells
诱导外周血间充质干细胞分化为牙齿结构形成细胞
基本信息
- 批准号:22791977
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Young Scientists (B)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Aiming the differentiation induction into odontoblasts from mesenchymal stem cells in the peripheral blood, establishment of the cells from dental pulp and bone marrow were performed. Their differentiation characterization was assessed by biochemical and histological analyses.The cells established from dental pulp expressed odontoblast specific markers, and was capable of generating dentin tissue. In the study on GFP transplantation model, bone marrow derived cells were established as a peripheral blood derived cells. The analyses of this primary culture cells revealed that stem cell like cells exist in the bone marrow, which can differentiate into tooth structure forming cells in vivo. However, some cells, which also possess pluripotency, would not be engrafted by transplantation. These data indicated the possible presence of different types of stem cells in the bone marrow. These cells are encouraging cells that possess the possibility of new innovation in the regenerative dentistry.
瞄准外周血液中间充质干细胞的分化诱导,从牙髓和骨髓中建立细胞。通过生化和组织学分析评估它们的分化表征。根据牙浆建立的细胞表达了牙糖细胞特定标记,并能够产生牙本质组织。在GFP移植模型的研究中,将骨髓衍生的细胞确定为外围血液衍生细胞。对这种原代培养细胞的分析表明,骨髓中的干细胞类似细胞存在,可以分化为体内形成细胞的牙齿结构。但是,某些也具有多能性的细胞不会因移植而植入。这些数据表明骨髓中可能存在不同类型的干细胞。这些细胞鼓励细胞在再生牙科中具有新创新的可能性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effect of Fluoride-substituted Apatite on In Vivo Bone Formation
- DOI:10.1177/0885328209357109
- 发表时间:2011-05
- 期刊:
- 影响因子:2.9
- 作者:M. Inoue;A. Rodríguez;N. Nagai;H. Nagatsuka;R. Legeros;H. Tsujigiwa;Masahisa Inoue;E. Kishimoto;S. Takagi
- 通讯作者:M. Inoue;A. Rodríguez;N. Nagai;H. Nagatsuka;R. Legeros;H. Tsujigiwa;Masahisa Inoue;E. Kishimoto;S. Takagi
Immunolocalization of Notch signaling protein molecules in a maxillary chondrosarcoma and its recurrent tumor
上颌软骨肉瘤及其复发肿瘤中Notch信号蛋白分子的免疫定位
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:4.2
- 作者:Siar CH;et al.
- 通讯作者:et al.
Establishment of odontoblastic cells, which indicate odontoblast features both in vivo and in vitro
- DOI:10.1111/jop.12080
- 发表时间:2013-11-01
- 期刊:
- 影响因子:3.3
- 作者:Tsujigiwa, Hidetsugu;Katase, Naoki;Nagatsuka, Hitoshi
- 通讯作者:Nagatsuka, Hitoshi
Dickkopf (Dkk)-3 and β-catenin expressions increased in the transition from normal oral mucosal to oral squamous cell arcinoma
Dickkopf (Dkk)-3 和 β-catenin 表达在正常口腔粘膜向口腔鳞状细胞癌转变过程中增加
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:3.2
- 作者:村岡理奈,辻極秀次;中野 敬介 ,片瀬直樹,玉村 亮;富田 美穂子 ;岡藤 範正 ,長塚 仁;川 上敏行;Tsujigiwa H;Siar CH;Fujii M
- 通讯作者:Fujii M
Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma
- DOI:10.1111/j.1365-2559.2010.03594.x
- 发表时间:2010-07-01
- 期刊:
- 影响因子:6.4
- 作者:Sonoda, Ryotaro;Naomoto, Yoshio;Tanaka, Noriaki
- 通讯作者:Tanaka, Noriaki
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TSUJIGIWA Hidetsugu其他文献
TSUJIGIWA Hidetsugu的其他文献
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{{ truncateString('TSUJIGIWA Hidetsugu', 18)}}的其他基金
A new reconstruction method using intraosseous microenvironment reproduction system of segmental excision bone
节段切除骨骨内微环境再生系统重建新方法
- 批准号:
26462784 - 财政年份:2014
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Differentiation induction of bone marrow stem cells into tooth component cells
骨髓干细胞向牙齿成分细胞的分化诱导
- 批准号:
20791515 - 财政年份:2008
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Application of Immobilized Cytokine for Regeneration Medicine in Head and neck Region
固定化细胞因子在头颈部再生医学中的应用
- 批准号:
17591790 - 财政年份:2005
- 资助金额:
$ 2.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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牙髓血运重建中的微环境:阐明阻止成牙本质细胞分化的机制
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