Elucidation of mechanism for induction of intestinal mucosal immune response to develop effective oral vaccine

阐明诱导肠粘膜免疫反应的机制以开发有效的口服疫苗

• 批准号: 22791816
• 负责人: HASHIZUME Tomomi
• 金额: $ 1.08万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791816/
• 关键词: 腸管粘膜免疫; 分泌型IgA; サルモネラ; パイエル板; 経口投与型ワクチン; Salmonella; FTY-720; CCR7; 樹状細胞; 腸管膜リンパ節

Cell transfer experiments showed that PP, but not SP-cell transferred mice could elicit the Ag-specific intestinal IgA immunity against orally administered rSalmonella. Further, antigen priming solely occurred in PP induces Ag-specific intestinal IgA immunity. On the other hand, CCR7 signaling which is important for dendritic cell migration may not be essential for induction of Ag-specific intestinal IgA immunity.

细胞转移实验表明，PP（而不是SP细胞转移的小鼠）可能会引起针对口服rsalmonella的Ag特异性IgA免疫。此外，PP中仅发生抗原启动会诱导Ag特异性肠IgA免疫。另一方面，对于树突状细胞迁移至关重要的CCR7信号对于诱导Ag特异性肠道IgA免疫可能不是必不可少的。