VASOHIBIN1 expression and function in the nasal tissue

鼻组织中VASOHIBIN1的表达和功能

• 批准号: 22791565
• 负责人: SUZUKI Takahiro
• 金额: $ 0.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791565/
• 关键词: VASOHIBIN; 鼻腔; Vasohibin-1; 嗅上皮

Vasohibin-1 has been reported as a novel functional molecules which negatively regulated angiogenesis. It was suggested by our preliminary experiment that Vasohibin-1 might be involved in the expression of the olfactory receptor, so we verified the expression of Vasohibin-1 in the nasal tissue. Although we confirmed Vasohibin-1 expression in mouse nasal tissue by RT-PCR and immunostaining method, it was not observed on olfactory cells but endothelial cells. The result which supported our hypothesis of the regulation the olfactory receptor by Vasohibin-1 was not obtained.

Vasohibin-1 已被报道为一种负向调节血管生成的新型功能分子。我们的初步实验提示Vasohibin-1可能参与了嗅觉受体的表达，因此我们验证了Vasohibin-1在鼻组织中的表达。虽然我们通过RT-PCR和免疫染色方法证实了小鼠鼻组织中Vasohibin-1的表达，但在嗅觉细胞上却没有观察到它，而在内皮细胞上却观察到了Vasohibin-1的表达。没有获得支持我们的 Vasohibin-1 调节嗅觉受体假设的结果。