Preclinical research for the development of new treatment strategy to improve the outcomes of neuropathic pain management

开发新治疗策略以改善神经性疼痛治疗效果的临床前研究

• 批准号: 22791443
• 负责人: MIYAZAKI Rika
• 金额: $ 2.08万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791443/
• 关键词: 神経障害性疼痛; 薬物療法; ガイドライン; 麻薬系鎮痛薬; プレガバリン; デュロキセチン; アロディニア; 動物実験モデル; ヂュロキセチン

It has been reported that less than 50% neuropathic pain patients satisfactorily treated with drugs. It is possible that this low efficacy of drugs on neuropathic pain might be due to the prescription of drugs regardless of the origin of pain. We compared the efficacy of orally administered morphine, pregabalin, gabapentin and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition(TNT) model. In the TNT model, the tibial nerve is transected and the tibial nerve stump is transpositioned to the lateral aspect of the hindlimb. After TNT injury, mechanical allodynia and neuroma pain are observed. Morphine, pregabalin, gabapentin and duloxetine were administered orally and were examined the anti-allodynic and anti-neuroma pain effects. Morphine, pregabalin, gabapentin and duloxetine attenuated the level of mechanical allodynia in a dose-dependent manner. Morphine, but not pregabalin, gabapentin and duloxetine, attenuated the neuroma pain. Morphine was less potent in neuroma pain than in mechanical allodynia. In the two drugs combination studies(morphine+pregabalin, morphine+duloxetine and pregabalin+duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain. This data indicated that the potency of morphine and the efficacy of

据报道，用药物令人满意治疗的神经性疼痛患者少于50％。药物对神经性疼痛的这种低疗效可能是由于药物的处方所致，无论疼痛的起源如何。我们使用胫骨神经瘤转置（TNT）模型比较了口服的吗啡，gababalin，gabapentin和duloxetine对机械性异常的疗效与神经瘤疼痛的疗效。在TNT模型中，胫骨神经转移，胫骨神经残端转​​置向后肢的侧面。 TNT损伤后，观察到机械性异常性疼痛和神经瘤疼痛。口服服用吗啡，gababalin，gabapentin和duloxetine，并检查了抗神经毒素和抗神经瘤疼痛作用。吗啡，前伽巴林，加巴喷丁和杜洛西汀以剂量依赖性方式减弱了机械性异常性的水平。吗啡，但不是gababalin，gabapentin和duloxetine，减轻了神经瘤疼痛。吗啡在神经瘤疼痛中的有效性不如机械性异常性疼痛。在两种药物组合研究（吗啡+前gabalin，吗啡+杜洛西汀和前gabalin+duloxetine）中，所有药物组合都会对机械性异胞菌产生协同作用，但对神经瘤疼痛没有。这些数据表明吗啡的效力和

项目成果

(2010)神経損傷後のアロディニア・断端痛に対するプレガバリン、モルヒネ、トラマドールの効果

(2010) 普瑞巴林、吗啡和曲马多对神经损伤后异常性疼痛和残肢痛的影响

• 发表时间: 2010
• 作者: 宮崎里佳;山本達郎
• 通讯作者: 山本達郎

The Efficacy of Morphine, Pregabalin, Gabapentin, and Duloxetine on Mechanical Allodynia Is Different from That on Neuroma Pain in the Rat Neuropathic Pain Model

• DOI: 10.1213/ane.0b013e31824f94ca
• 发表时间: 2012-07-01
• 期刊: ANESTHESIA AND ANALGESIA
• 影响因子: 5.7
• 作者: Miyazaki, Rika;Yamamoto, Tatsuo
• 通讯作者: Yamamoto, Tatsuo

Efficacy of morphine, pregabalin, gabapentin and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model

吗啡、普瑞巴林、加巴喷丁和度洛西汀对大鼠神经病理性疼痛模型中机械性异常性疼痛的疗效与对神经瘤疼痛的疗效不同

• 发表时间: 2012
• 期刊: Anesth Analg
• 影响因子: 5.7
• 作者: Miyazaki R;Yamamoto T
• 通讯作者: Yamamoto T