Genome-wide association study of schizophrenia in a Japanese population and follow-up study

日本人群精神分裂症的全基因组关联研究及后续研究

• 批准号: 22791120
• 负责人: ALEKSIC Branko
• 金额: $ 2.5万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791120/
• 关键词: JGWAS; MAGI2; 統合失調症; 認知機能; 実行機能; 認知機能障害; 全ゲノム関連解析; WCST; 関連研究

A synapse scaffolding protein, MAGI2, interacts with a variety of functional molecules including glutamate receptors and is presumed to be relevant to cognitive impairment in schizophrenia. In this study, we conducted an association analysis of MAGI2 in schizophrenia and evaluated an effect of this gene on cognitive function. As a result, two polymorphisms(rs2190665、rs4729938) showed suggestive evidence of association with schizophrenia. In addition, rs2190665 was found to be related to impairment of executive function.

突触脚手架蛋白Magi2与包括谷氨酸受体在内的多种功能分子相互作用，并且与精神分裂症的认知障碍有关。在这项研究中，我们对精神分裂症进行了MAGI2的关联分析，并评估了该基因对认知功能的影响。结果，两种多态性（rs2190665，rs4729938）显示出暗示性的与精神分裂症相关的证据。此外，发现RS2190665与执行功能的损害有关。

项目成果

Association study and expression analysis between MAGI2 and schizophrenia

MAGI2与精神分裂症的关联研究及表达分析

• 发表时间: 2011
• 作者: Koide T;Aleksic B;Yoshimi A;et al.
• 通讯作者: et al.

Overview of the single SNP analysis of Japanese genome wide association study of schizophrenia

日本精神分裂症全基因组关联研究单SNP分析综述

• 发表时间: 2010
• 作者: Koide T;Aleksic B;Yoshimi A;et al.;Aleksic Branko
• 通讯作者: Aleksic Branko

A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

二氢嘧啶酶样 2 基因 (DPYSL2) 与日本受试者精神分裂症的两阶段病例对照关联研究

• 发表时间: 2010
• 期刊: J Hum Genet
• 影响因子: 3.5
• 作者: Koide T;Hashimoto R;et al.
• 通讯作者: et al.

Copy Number Variation in Schizophrenia in the Japanese Population

• DOI: 10.1016/j.biopsych.2009.08.034
• 发表时间: 2010-02-01
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Ikeda, Masashi;Aleksic, Branko;Iwata, Nakao
• 通讯作者: Iwata, Nakao