Pathomehcanism of lumbar ligamentum flavum hypertrophy

腰椎黄韧带肥厚的病理机制

• 批准号: 22591636
• 负责人: SAIRYO Koichi
• 金额: $ 2.91万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591636/
• 关键词: 黄色靭帯肥厚; 腰部脊柱管狭窄症; 線維増殖性疾患; 黄色靭帯; 靭帯肥厚; ペントシジン; コラーゲン架橋; 黄色靱帯肥厚; 肥厚性瘢痕; アルファ平滑筋アクチン; I型コラーゲン; III型コラーゲン

The pathomechanism of hypertrophy of ligamentum flavum (LF) is still unknown. We hypothesized that the mechanism would be similar to that in the hypertrophic scar formation during the would repair of skin. The pathology is considered to be fibro-proliferative disorder (FPD). To confirm the hypothesis, we have investigated the similarity of the hypertrophy of LF and hypertrophic scar. Hypertrophied LF samples were taken during the lumbardecompression surgery. Masson Trichlome (MT) and Elastica van Gieson (EVG) stain were uded to understand the scar and fibrosis. The similarity of FPD was investigated using the immunohistochemistry of type 1 and 3 collagen and alfa-smooth muscle antigen (αSMA). In the hypertrophied LF, elastic fiber was stained sparse, especially along the dorsal aspect in LF. Instead, scar and fibroscic tissue was confirmed in the LF. At the scarring site, type 1 and 3 collagen was stained. The αSMA was also confirmed to be stained. Thus, hypertrophy of LF would be a type of the fibro-proliferative disorder. The other major matrix of the normal LF is type 1 collagen. We evaluated the bad crosslink in collagen named Pentocidine, which reduces the ligament elasticity . We confirmed the existence of the pentocidine in LF, especially at the cite where type 1 collagen showed abundant production.

韧带的病理（LF）仍然未知。将肥大的LF样品g进行了腰部压缩手术。 ）。该评估的其他主要基质在名为五一个的胶原蛋白中评估了不良的交叉链接，该胶原蛋白降低了韧带弹性。

项目成果

Biomechanical rationale of sacral rounding deformity in pediatric spondylolisthesis: a clinical and biomechanical study

• DOI: 10.1007/s00402-010-1257-2
• 发表时间: 2011-01
• 期刊: Archives of Orthopaedic and Trauma Surgery
• 影响因子: 2.3
• 作者: T. Terai;K. Sairyo;V. Goel;N. Ebraheim;A. Biyani;Faizan Ahmad;A. Kiapour;Kosaku Higashino;T. Sakai;N. Yasui

The pathomechanism of the ligamentum flavum hypertrophy is similar to that of the hypertrophic scar formation during wound healing

黄韧带肥厚的病理机制与伤口愈合过程中增生性疤痕形成的机制相似

• 发表时间: 2011
• 作者: Sairyo K;Kanamori Y;Ogawa R;Goel V ,Biyani A;Ebraheim N;Dezawa A
• 通讯作者: Dezawa A

Proteomic analysis of ligamentum flavum from lumbar spinal canal stenosis

腰椎管狭窄症黄韧带的蛋白质组学分析

• 发表时间: 2013
• 作者: Yuichiro Goda;Nori Sato;Takako Taniguchi;Yoichiro Takata;Hirofumi Kosaka;Toshinori Sakai;Kosaku Higashino;Koichi Sairyo;Shinsuke Katoh;Hisaaki Taniguchi;Natsuo Yasui
• 通讯作者: Natsuo Yasui

Painful lumbar spondylolysis among pediatric sports players: a pilot MRI study

• DOI: 10.1007/s00402-011-1336-z
• 发表时间: 2011-11-01
• 期刊: ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
• 影响因子: 2.3
• 作者: Sairyo, Koichi;Sakai, Toshinori;Dezawa, Akira
• 通讯作者: Dezawa, Akira

Two types of laminolysis in adolescent athletes.

• DOI: 10.1007/s10195-012-0206-y
• 发表时间: 2012-12
• 期刊: JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
• 影响因子: 2.8
• 作者: Miyagi, Ryo;Sairyo, Koichi;Sakai, Toshinori;Yoshioka, Hiroshi;Yasui, Natsuo;Dezawa, Akira
• 通讯作者: Dezawa, Akira