Investigation of the molecular mechanism of invasion in CNS lymphomausing inoculation animal models in the brain and development of noveltreatment

中枢神经系统淋巴瘤接种动物模型脑侵袭分子机制研究及新疗法开发

• 批准号: 22591615
• 负责人: MAKINO Keishi
• 金额: $ 2.91万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591615/
• 关键词: 脳腫瘍学; 悪性リンパ腫; fatty acid synthase; IDH1; エネルギー代謝; 中枢神経; 悪性腫瘍; glucose transporter 1; 動物モデル; 浸潤; eIF4E; α2,6-sialyltransferase

In order to identify the molecules related to growth and invasion ofcentral nervous system (CNS) lymphoma, we investigated the expression of glucosetransporter 1 (Glut 1), fatty acid synthase (F AS) and 2, 6-sialyltransferase. Weperformed immunohistochemical analysis using specific antibodies for each molecule. Intwenty-three of twenty-five cases with CNS lymphomas and all nine cases with CNSinvasion of systemic lymphoma, positive expression of 2,6-sialyltransferase was found.Furthermore, positive expression of F AS was found in 70.3 % and that of Glut 1 was foundin 44.4 % of twenty-seven cases with lymphomas. These data suggested that thesemetabolic or invasion related molecules might be novel therapeutic targets for CNSlymphoma

为了鉴定与生长和浸润性内膜神经系统（CNS）淋巴瘤有关的分子，我们研究了葡萄糖量抗孢子1（GLUT 1），脂肪酸合酶（F AS）和2，6-溶解酶的表达。使用每个分子的特异性抗体，WEPERFORMENFORMENTING HAMENOISCHICAL分析。在二十五例CNS淋巴瘤和所有九个患有全身性淋巴瘤的CNSINSINICAMAS的病例中，发现了2,6-溶酶体的阳性表达。Furthermore，F lut 1的阳性F表达如70.3％，而Glut 1的阳性表达为44.4％的lymphomas in Twy-See-See-Seever in Twy-See-Seven均为44.4％。这些数据表明，这些代谢或侵袭相关的分子可能是CNSlymphoma的新型治疗靶标

项目成果

M2 Macrophage/Microglial Cells Induce Activation of Stat3 in Primary Central Nervous System Lymphoma

• DOI: 10.3960/jslrt.51.93
• 发表时间: 2011-11-01
• 期刊: JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY
• 影响因子: 1.5
• 作者: Komohara, Yoshihiro;Horlad, Hasita;Takeya, Motohiro
• 通讯作者: Takeya, Motohiro

Population-based epidemiological study of primary intracranial tumors in childhood

• DOI: 10.1007/s00381-010-1126-x
• 发表时间: 2010-08-01
• 期刊: CHILDS NERVOUS SYSTEM
• 影响因子: 1.4
• 作者: Makino, Keishi;Nakamura, Hideo;Kuratsu, Jun-ichi
• 通讯作者: Kuratsu, Jun-ichi

悪性脳腫瘍におけるfatty acid synthaseの発現とその意義

脂肪酸合酶在恶性脑肿瘤中的表达及意义

• 发表时间: 2011
• 作者: 牧野敬史;他
• 通讯作者: 他

二次性脳内悪性リンパ腫の治療成績の検討

继发性脑内恶性淋巴瘤的治疗效果检查

• 发表时间: 2010
• 作者: 牧野敬史;他;東 洋一郎;八幡 俊男;牧野敬史
• 通讯作者: 牧野敬史

Risk of primary childhood brain tumors related to season of birth in Kumamoto Prefecture, Japan

• DOI: 10.1007/s00381-010-1235-6
• 发表时间: 2011-01-01
• 期刊: CHILDS NERVOUS SYSTEM
• 影响因子: 1.4
• 作者: Makino, Keishi;Nakamura, Hideo;Kuratsu, Jun-ichi
• 通讯作者: Kuratsu, Jun-ichi