The Clinical Trial of Novel Biodegradable External Film Releasing Rapamycin for CABG

新型可生物降解缓释雷帕霉素外膜用于冠状动脉搭桥术的临床试验

• 批准号: 22591532
• 负责人: ODA Katsuhiko
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591532/
• 关键词: Drug-delivery system; 循環器; 心臓外科; 臨床; 虚血性心疾患; 循環器・高血圧; 冠動脈バイパス手術; 吻合部狭窄; 内膜肥厚; ＤＤＳ

To develop a novel technology to prevent saphenous vein grafts stenosis in CABG, the clinical trial of external application of rapamycin-eluting film at anastomotic sites was conducted. During the study period, total 21 patients had been enrolled in this study, and no graft occlusion and no adverse effect of this film was observed. With this clinical trial, the safety and feasibility of this new DDS system have been established.

为了开发一种新的技术来预防CABG中的隐性静脉移植狭窄，进行了在吻合部位的外部应用雷帕霉素洗脱膜的临床试验。在研究期间，总共有21名患者参加了这项研究，没有观察到该膜的移植术，也没有观察到不良影响。通过这项临床试验，已经建立了这种新DDS系统的安全性和可行性。

项目成果

ラパマイシン徐放フィルムを用いた冠動脈吻合部狭窄予防の臨床応用

雷帕霉素缓释膜预防冠状动脉吻合口狭窄的临床应用

• 发表时间: 2011
• 作者: Ishiwata T;Matsuda Y;Yamamoto T;Uchida E;Korc M;Naito Z;川本俊輔
• 通讯作者: 川本俊輔