Analysis of the low invasive surgical treatment effect and dynamic state of adipose cell origin hormone of morbid obesity patients

病态肥胖患者低创手术治疗效果及脂肪细胞来源激素动态分析

• 批准号: 22591440
• 负责人: SASAKI Akira
• 金额: $ 1.75万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591440/
• 关键词: 肥満症; 糖尿病; アディポサイトカイン; レプチン; アディポネクチン; 遺伝子多型; 代謝栄養外科学

In this research, for morbid obesity patients (BMI>=35 k g/m2 with comorbidities) underwent laparoscopic sleeve gastrectomy (LSG), the dynamic state of adipocytokines such as ghrelin and leptin which play an important role in development of symptoms of metabolic syndrome is analyzed (primary point). Furthermore, the purpose of analyzing the molecular mechanism in connection with an obesity patient's morbidity formation, the adipocytokine secretion ability in the gene polymorphism of an insulin resistance related gene and thevisceral fat primary culture cell which carried out separation cultivation is examined.And methylation analysis of an overweight related gene and microarray analysis using mRNA are also conducted (secondary point). By the LSG group, even if high leptin and adiponectin the blood kinetics of low adiponectin were clea r and compared with the control group, it was a significant change. The dynamic state of leptin and adiponectin showed the same dynamic state by in vivo and in vitro, and a possibility that these were produced by visceral fat cell dependence was suggested. Overweight related gene polymorphism accepted some AG of UCP1, and GG types with the LSG case. Although the tendency for BMI to be high was seen in the patients withAG of UCP1, a difference was not observed in the postoperative weight loss effect. The dynamic state of leptin and adiponectin showed the same dynamic state by in vivo and in vitro, and these were produced by visceral fat cell dependence. Therefore, in the morbid obesity to which the adipocytokines production profile was set highly from the first, irrespective of gene polymorphism, an adipocytokines production profile may fall and an effect may be able to expect an individual from the first irrespective of gene pol ymorphism by LSG.

在这项研究中，对于病态肥胖患者（BMI> = 35 k g/m2的合并症）进行了腹腔镜袖胃切除术（LSG），这是脂肪细胞因子的动态状态，例如Ghrelin and Leptin和Leptin，在症状中起重要作用，在分析症状中起重要作用。此外，与肥胖患者的发病率形成相关的分子机制的目的通过LSG组，即使高瘦素和脂联素也是脂联素低的血液动力学，并与对照组进行了比较，但这是一个重大变化。瘦素和脂联素的动态状态通过体内和体外表现出相同的动态状态，并提出了它们是由内脏脂肪细胞依赖性产生的。与超重基因多态性相关的基因多态性接受了LSG病例的UCP1的某些AG和GG类型。尽管在UCP1的患者中看到了BMI高的趋势，但在术后减肥效应中未观察到差异。瘦素和脂联素的动态状态通过体内和体外表现出相同的动态状态，并且这些动态状态是通过内脏脂肪细胞依赖性产生的。因此，在病态肥胖症中，脂肪细胞的生产概况是从第一个，无论基因多态性而不考虑的，脂肪细胞因子的生产概况可能会下降，并且效果可能会产生效果，而不管LSG的基因pol Ymorphorm pol ymorphism by lsg by lsg的第一个。

项目成果

特集「肥満と外科治療」7.腹腔鏡下調節性胃バンディング術.

专题“肥胖与手术治疗”7.腹腔镜可调式胃束带手术。

• 发表时间: 2011
• 期刊: 月間糖尿病
• 作者: 佐々木章;若林剛;佐々木章;佐々木章
• 通讯作者: 佐々木章

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• 发表时间: 2011
• 作者: 梅邑晃;佐々木章;馬場誠朗 ;大渕徹;長谷川康;高原武志;西塚哲;木村祐輔;新田浩幸;大塚幸喜;肥田圭介;水野大;若林剛;佐々木 章;梅邑 晃;佐々木 章
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Metabolic Surgery の現況と課題:認定制度準備委員会からの現状

代谢外科的现状和挑战：认证体系准备委员会的现状

• 发表时间: 2012
• 作者: 佐々木章;馬場誠朗 ;大渕徹;長谷川康;高原武志;西塚哲;木村祐輔;新田浩幸;大塚幸喜;肥田圭介;水野大; 若林剛
• 通讯作者: 若林剛

新しい肥満症治療の進め方 5. 術後管理の仕方新しい肥満症治療の進め方(日本肥満症治療学会編ガイドライン)

肥胖治疗的新方法 5.术后如何管理 肥胖治疗的新方法（日本肥胖治疗学会编撰指南）

• 作者: 佐々木章;若林剛
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腹腔鏡下スリーブ状胃切除術後の非アルコール性肝疾患改善の定量的評価

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• 发表时间: 2012
• 作者: 馬場誠朗;佐々木章;大渕徹;長谷川康;高原武志;西塚哲;木村祐輔;新田浩幸;大塚幸喜;肥田圭介;水野大; 若林剛
• 通讯作者: 若林剛