Analysis of the roles of anamorsin, anti-apoptotic molecule, onsurvival and proliferation of B lymphocytes

抗凋亡分子阿莫辛对B淋巴细胞存活和增殖的作用分析

• 批准号: 22591034
• 负责人: SHIBAYAMA Hirohiko
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591034/
• 关键词: アナモルシン; Picot; 鉄・硫黄クラスター; B リンパ球; 遺伝子改変マウス; LPS; ERK1/2; IkB; Bリンパ球; PICOT; PKC; p38MAPK; P38MAPK

The proliferation of B lymphocytes (B) from anamorsin (AM) transgenic (Tg) mice by LPS was impaired compared with WT B. The Western blotting analysis showed the phosphorylation of ERK1/2 and IkB were reduced. Furthermore, the expression of IL-1β mRNA was decreased in AM Tg B by DNA array compared with WT B. From these data, it was clarified that AM overexpression had negative effects on LPS-induced signal pathways of B.

与WT B相比，LPS从Anamorsin（AM）转基因（TG）小鼠中B淋巴细胞（B）的增殖受损。蛋白质印迹分析显示ERK1/2和IKB的磷酸化降低了。此外，与WT B相比，DNA阵列在AM TG B中降低IL-1βMRNA的表达。从这些数据中，可以澄清，AM过表达对B.

项目成果

Detection of change in LIC by MRI in a transfusion dependent MDS patient treated with deferasirox

通过 MRI 检测接受地拉罗司治疗的输血依赖性 MDS 患者的 LIC 变化

• 作者: Hamanaka Y;et al
• 通讯作者: et al

An anti-apoptotic molecule, Anamorsin, functions in both Fe/S cluster assembly and iron homeostasis

抗凋亡分子 Anamorsin 在 Fe/S 簇组装和铁稳态中发挥作用

• 发表时间: 2012
• 作者: Tanimura A;Hamanaka Y;Tanaka H;Matsumura I;Oritani K;Shibayama H;Kanakura Y et al
• 通讯作者: Kanakura Y et al

OLSG 参加施設 . Clinical prognostic analysis of 465 follicular lymphoma (FL) cases from OLSG (Osaka Lymphoma Study Group) registry: OLSG cohort analysis

OLSG 参与机构对 OLSG（大阪淋巴瘤研究组）登记处的 465 例滤泡性淋巴瘤 (FL) 病例进行临床预后分析：OLSG 队列分析

• 发表时间: 2011
• 作者: 山本克也;他:;原田結花，原田浩徳;小原尚恵,柴山浩彦,武 弘典,魚嶋伸彦,服部英喜,畦西恭彦,菅原浩之,橋本光司,日野雅之,冨永信彦,青笹克之,金倉 譲
• 通讯作者: 小原尚恵,柴山浩彦,武 弘典,魚嶋伸彦,服部英喜,畦西恭彦,菅原浩之,橋本光司,日野雅之,冨永信彦,青笹克之,金倉 譲

for the Japanese AMN107/2303 Study Group. Nilotinib as frontline therapy for patients with newly diagnosed Ph+ chronic myeloidleukemia in chronic phase: results from the Japanese subgroup of ENESTnd

日本 AMN107/2303 研究组。

• 发表时间: 2011
• 期刊: Int J Hematol
• 影响因子: 2.1
• 作者: Nakamae H;Shibayama H;Kurokawa M;Fukuda T;Nakaseko C;Kanda Y;Nagai T;Ohnishi K;Maeda M;Matsuda A;Amagasaki T;Yanada M
• 通讯作者: Yanada M

Nilotinib versus imatinib for newly-diagnosed CML-CP : ENESTnd 24-month update in Japanese patients

尼洛替尼与伊马替尼治疗新诊断的 CML-CP：ENESTnd 日本患者 24 个月更新

• 发表时间: 2011
• 作者: Nakaseko C;Nakamae H;Shibayama H;et al
• 通讯作者: et al