Effects of renal tissue-specific NFkB blockade on aging kidneys

肾组织特异性 NFkB 阻断对衰老肾脏的影响

• 批准号: 22590897
• 负责人: OKADA Hirokazu
• 金额: $ 1.58万
• 依托单位: Saitama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590897/
• 关键词: 老化; NFkB 経路; 線維化; 遺伝子改変動物; 尿細管上皮細胞; NFkB; 腎線維化; 線維芽細胞; ポドサイト; NFkBシグナル; 糸球体硬化

We generated genetically-modified mice, gGT.Cre:IkBdN mice, in which the NFkB pathway is blocked exclusively in tubular epithelium. In the kidney of wild-type mice at 20 month-old, peritubular fibrosis was observed compared to those at 3 moth-old, which seemed to be an age-related, histological change. In contrast, peritubular fibrosis was significantly enhanced in the kidney of gGT.Cre:IkBdN mice at 20 month-old. Therefore, long-term blockade of NFkB pathway in tubular epithelium was supposed to accelerate renal fibrogenesis.

我们产生了遗传改性的小鼠GGT.CRE：IKBDN小鼠，其中NFKB途径仅在管状上皮中被阻断。在20个月大的野生型小鼠的肾脏中，观察到周围纤维化与3个蛾类的肾脏相比，这似乎是与年龄相关的组织学变化。相比之下，GGT.CRE的肾脏：20个月大的IKBDN小鼠的周围纤维化显着增强。因此，在管状上皮中的NFKB途径的长期阻塞被认为加速肾纤维发生。

项目成果

Targeted Inhibition of NF-kB Activation in Tubular Epithelia Protects Mice Against Renal Fibrogenesis Following NTN

靶向抑制肾小管上皮细胞中 NF-kB 的激活可保护小鼠 NTN 后免受肾纤维化

• 发表时间: 2011
• 作者: T.Inoue;他
• 通讯作者: 他

Non-cell-autonomous tumor suppression by p53.

• DOI: 10.1016/j.cell.2013.03.020
• 发表时间: 2013-04-11
• 期刊: Cell
• 影响因子: 64.5
• 作者: Lujambio A;Akkari L;Simon J;Grace D;Tschaharganeh DF;Bolden JE;Zhao Z;Thapar V;Joyce JA;Krizhanovsky V;Lowe SW
• 通讯作者: Lowe SW