Analyses of liver-specific miRNA function and the development of the strategy about the efficient induction of differentiation into hepatocytes

肝脏特异性miRNA功能分析及高效诱导肝细胞分化策略开发

• 批准号: 22590718
• 负责人: KONDO Yuuji
• 金额: $ 2.83万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590718/
• 关键词: 肝臓学; microRNA; 分化; 肝細胞; 肝癌; AFP; microRNA122; 癌幹細胞; 肝細胞癌

Liver specific miR122 is frequently downregulated in hepatocellular carcinoma (HCC). Knockdown of miR122 induces AFP expression, indicating the de-differentiation of hepatocytes. Decreased miR122 expression leads to the increased expression of CUX1, a transcriptional factor, which is related with the aggressiveness of HCC. From these results, decreased miR122 results in the AFP expression and aggressiveness of HCC, which is a molecular explanation about the clinical poor prognosis of HCCs with high AFP expression.

肝脏特异性 miR122 在肝细胞癌 (HCC) 中经常下调。 miR122 的敲低会诱导 AFP 表达，表明肝细胞去分化。 miR122表达减少导致转录因子CUX1表达增加，这与HCC的侵袭性有关。从这些结果来看，miR122的减少导致了AFP表达和HCC的侵袭性，这是AFP高表达的HCC临床预后不良的分子解释。

项目成果

MicroRNA122 is a key regulator of alpha-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma

MicroRNA122是甲胎蛋白表达的关键调节因子并影响肝细胞癌的侵袭性

• 发表时间: 2011
• 期刊: Nat Commun
• 影响因子: 16.6
• 作者: Kojima K;Takata A;Vadnais C;Otsuka M;Yoshikawa T;Akanuma M;Kondo Y;Kang YJ;Kishikawa T;Kato N;Xie Z;Zhang WJ;Yoshida H,Omata M;Nepveu A;Koike K
• 通讯作者: Koike K

A phise I/II trial of the oral antiangiogenic agent TSU-68 in patients with advanced hepatocellular carcinoma.

口服抗血管生成剂 TSU-68 在晚期肝细胞癌患者中的 I/II 期试验。

• 发表时间: 2011
• 期刊: Cancer Chemother Pharmacol.
• 作者: Kanai F;Yoshida H;Tateishi R;Sato S;Kawabe T;Obi S;Kondo Y;Taniguchi M;Tagawa K;Ikeda M;Morizane C;Okusaka T;Arioka H;Shiina S;Omata M.
• 通讯作者: Omata M.

Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors.

• DOI: 10.1038/ajg.2011.425
• 发表时间: 2012-04
• 期刊: AMERICAN JOURNAL OF GASTROENTEROLOGY
• 影响因子: 9.8
• 作者: Shiina, Shuichiro;Tateishi, Ryosuke;Arano, Toru;Uchino, Koji;Enooku, Kenichiro;Nakagawa, Hayato;Asaoka, Yoshinari;Sato, Takahisa;Masuzaki, Ryota;Kondo, Yuji;Goto, Tadashi;Yoshida, Haruhiko;Omata, Masao;Koike, Kazuhiko
• 通讯作者: Koike, Kazuhiko

Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times.

通过肿瘤标志物倍增时间的变化评价分子靶向抗癌药物。

• DOI: 10.1007/s00535-011-0462-2
• 发表时间: 2012
• 期刊: J Gastroenterol.
• 作者: Akita S;Yoshimoto H;Hirano A;Ohtsuru A;Yamashita S.;Kondo Y et al. (10人中4番目)
• 通讯作者: Kondo Y et al. (10人中4番目)

経皮的ラジオ波焼灼術の安全性と合併症対策

经皮射频消融术的安全性及并发症处理

• 发表时间: 2012
• 作者: 三浦光一;大西洋英;近藤祐嗣
• 通讯作者: 近藤祐嗣