Epigenetic control of microRNA in the development gastric carcinomas in the elderly

microRNA在老年人胃癌发展中的表观遗传控制

• 批准号: 22590329
• 负责人: ARAI Tomio
• 金额: $ 2.91万
• 依托单位: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590329/
• 关键词: 胃癌; 加齢; microRNA; 高齢者; マイクロサテライト不安定性; 分化型癌; 未分化型癌

Gastric cancer is representative malignant neoplasm which increases with aging, and its carcinogenesis has been commonly studied based on the histological classification : differentiated type and undifferentiated type. However, gastric cancer often has histologic diversity within the tumor and it is difficult to explain a close relationship between histological classification and carcinogenesis. Therefore, we examined microsatellite instability (MSI) as a marker and found that MSI was significantly related with older age, occurrence in women, papillary adenocarcinoma and solid-type poorly differentiated adenocarcinoma. Unlike colorectal cancer, MSI was not associated with microRNA profile in gastric cancer. This may be due to variety of gastric cancer. Then, we focused on gastric poorly differentiated adenocarcinoma which often occurred in the elderly and found that microRNA profile in solid-type poorly cancer was different from that in nonsolid-type cancer. This result indicated that solid-type cancer may develop in the different way from nonsolid-type cancer.

胃癌是随着年龄增长而增加的代表性恶性肿瘤，其癌变机制通常根据组织学分类：分化型和未分化型来研究。然而，胃癌肿瘤内往往具有组织学多样性，很难解释组织学分类与癌发生之间的密切关系。因此，我们检查了微卫星不稳定性（MSI）作为标志物，发现MSI与高龄、女性发病、乳头状腺癌和实性低分化腺癌显着相关。与结直肠癌不同，MSI 与胃癌中的 microRNA 谱无关。这可能是由于多种胃癌所致。然后，我们关注常见于老年人的胃低分化腺癌，发现实体型低分化癌的microRNA谱与非实体型癌不同。该结果表明实体型癌症可能以与非实体型癌症不同的方式发展。

项目成果

消化器内視鏡学会特別企画内視鏡医のための病理セッションBarrett食道の病理

胃肠内窥镜学会内窥镜医师病理学会议特别活动巴雷特食管病理学

• 发表时间: 2011
• 作者: 新井冨生;沢辺元司;吉田雅一;菊池いな子;古屋智子;新井冨生
• 通讯作者: 新井冨生

hTERT promoter polymorphism, -1327OT, is associated with the risk of epithelial cancer.

hTERT 启动子多态性 -1327OT 与上皮癌的风险相关。

• 发表时间: 2013
• 期刊: Springer Plus
• 作者: Iizuka T;Sawabe M;Kaiyo Takubo K;Liu M;Homma Y;Suzui M;Arai T.
• 通讯作者: Arai T.

マイクロサテライト不安定性を示す大腸癌の臨床病理学的特徴

显示微卫星不稳定性的结直肠癌临床病理特征

• 发表时间: 2010
• 作者: 新井冨生;玉橋うらら;沢辺元司;本間尚子;相田順子;田久保海誉
• 通讯作者: 田久保海誉

髄様型低分化大腸癌の発生経路と組織発生に関する病理学的検討

髓样低分化结直肠癌发生发展途径及组织发生的病理学检查

• 发表时间: 2011
• 作者: 新井冨生;櫻井うらら;沢辺元司;金澤伸郎;黒岩厚二郎;潮靖子;本間尚子;相田順子;田久保海誉
• 通讯作者: 田久保海誉

Alcoholics show reduced telomere length in the oesophagus

• DOI: 10.1002/path.2817
• 发表时间: 2011-02-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Aida, Junko;Yokoyama, Akira;Takubo, Kaiyo
• 通讯作者: Takubo, Kaiyo