Development of pioneering therapy for early atherosclerosis using novel S1P donor

使用新型 S1P 供体开发早期动脉粥样硬化的开创性疗法

• 批准号: 22590139
• 负责人: FUJII Satoshi
• 金额: $ 2.83万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590139/
• 关键词: 生理活性; 脂質; 薬学; 臨床; 内皮前駆細胞; 動脈硬化症; ナノ粒子; HDL

A novel strategy for conquering atherosclerosis is desirable. Athero-protective HDL is rich in bioactive lipid, sphingosine-1-phosphate (S1P). The effect of S1P on vascular endothelial cells was clarified. The relationship between plasma S1P and vascular endothelial function was evaluated. A newly synthesized biomimetic HDL nanoparticle rich in both S1P and apoA1 exhibited promising anti-inflammatory effects on endothelial cells in culture and on mice challenged with LPS.

需要一种征服动脉粥样硬化的新策略。动脉粥样硬化HDL富含生物活性脂质，鞘氨醇1-磷酸盐（S1P）。阐明了S1P对血管内皮细胞的影响。评估了血浆S1P与血管内皮功能之间的关系。富含S1P和APOA1的新合成的仿生HDL纳米颗粒对培养物中内皮细胞以及对LPS挑战的小鼠都表现出有希望的抗炎作用。

项目成果

金ナノ粒子を核とした人工 HDL ナノ粒子の調製と物性評価

以金纳米粒子为核心的人工HDL纳米粒子的制备及物性评价

• 发表时间: 2012
• 作者: 高橋 朋弘; 田上 辰秋; 岩城 壮一郎; 藤井 聡; 尾関 哲也
• 通讯作者: 尾関 哲也

S1Pが血液線溶系に与える影響の解明

阐明S1P对血液纤溶系统的影响

• 发表时间: 2013
• 作者: 真川明将;岩城壮一郎;浅井萌子;榊原大輔;山村周平;藤井聡
• 通讯作者: 藤井聡

Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by cAMP in HepG2 liver cells

• DOI: 10.1093/jb/mvr110
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF BIOCHEMISTRY
• 影响因子: 2.7
• 作者: Asakura, Takefumi;Iwaki, Soichiro;Fujii, Satoshi
• 通讯作者: Fujii, Satoshi

Increased expression of PAI-1 in HepG2 cells induced by insulin mediated by the 3'-untranslated region of the PAI-1 gene and its pharmacologic implications.

PAI-1 基因 3-非翻译区介导的胰岛素诱导 HepG2 细胞中 PAI-1 表达增加及其药理学意义。

• 发表时间: 2010
• 期刊: Coronary Artery Disease
• 影响因子: 1.8
• 作者: Miyagawa R;Asakura T;Nakamura T;Okada H;Iwaki S;Sobel B;Fujii S.2010
• 通讯作者: Fujii S.2010

Waist circumference can predict the occurrence of multiple metabolic risk factors in middle-aged Japanese subjects.

腰围可以预测日本中年受试者多种代谢危险因素的发生。

• 发表时间: 2010
• 期刊: Industrial Health
• 影响因子: 2
• 作者: Satoh H;Fujii S;Furumoto T;Kishi R;Tsutsui H.
• 通讯作者: Tsutsui H.