Pathogenesis of newly described developmental abnormality induced in the kidney of rhesus monkey offspring by in utero and lactational e xposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

子宫内和哺乳期暴露于 2,3,7,8-四氯二苯并-对二恶英引起的恒河猴后代肾脏发育异常的发病机制

• 批准号: 22510073
• 负责人: FUKUSATO Toshio
• 金额: $ 2.91万
• 依托单位: Teikyo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22510073/
• 关键词: 内分泌かく乱物質; ほ乳類; ダイオキシン; TCDD; 腎形成異常; dysplasia; sox2; prostaglandin; 次世代; 腎; 形成異常; ダイオキシン(TCDD); 腎病変; 腎尿細管; レニン・アンギオテンシン系

We for the first time described developmental abnormality with renal dysplasia induced in the kidney of rhesus monkey offspring exposed during prenatal and lactational period to TCDD. The renal lesions developed exclusively in offspring of dams exposed to relatively high dose (300ng/kg) of TCDD. We disclosed disturbed cox2-prostaglandin system as pathogenesis of the renal lesion.

我们首次描述了在TCDD期间暴露于产前和泌乳期间暴露于恒河猴后代的肾脏发育不良的发育异常。肾脏病变仅在暴露于TCDD剂量相对较高剂量（300ng/kg）的大坝后代发展。我们将受干扰的COX2-促素蛋白系统揭示为肾脏病变的发病机理。

项目成果

Gestational and Lactational Exposure to 2,3,7,8-tetrachlorodibenzo-p-Dioxin (TCDD) Induces Abnormal Development of the Kidney in Offspring of Rhesus Monkeys

妊娠期和哺乳期接触 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 会导致恒河猴后代肾脏发育异常

• 发表时间: 2011
• 期刊: Organohalogen Compounds
• 作者: Shunichiro Kubota;Toshio Fukusato
• 通讯作者: Toshio Fukusato

ダイオキシンの胎生期および授乳期暴露後の仔アカゲザル腎におけるCox2、CYP1A1、HSP70の発現

胚胎期和哺乳期接触二恶英后幼恒河猴肾脏中 Cox2、CYP1A1 和 HSP70 的表达

• 发表时间: 2012
• 作者: 福里利夫;高橋芳久;久保田俊一郎
• 通讯作者: 久保田俊一郎

Enhanced expression of cox2 and cyp1a1 in early active renal lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during gestation and lactation

妊娠期和哺乳期暴露于 2,3,7,8-四氯二苯并-对二恶英 (TCDD) 的恒河猴后代早期活动性肾损伤中 cox2 和 cyp1a1 的表达增强

• 发表时间: 2012
• 期刊: Organohalogen Compounds
• 作者: Toshio Fukusato;Masato Watanabe,Shunichiro Kubota;Akihiro Arima;Atsunobu Muneoka;Hiroshi Sumida;Mineo Yasuda
• 通讯作者: Mineo Yasuda

ダイオキシンの胎生期および授乳期暴露後の仔アカゲザル腎におけるCox2、CYP1A1、HSP70 の発現

胎儿和哺乳期接触二恶英后幼恒河猴肾脏中 Cox2、CYP1A1 和 HSP70 的表达

• 发表时间: 2012
• 作者: 渡邉雅人;高橋芳久;有馬昭宏;宗岡篤信;墨田 寛;安田峯生; 久保田俊一郎;福里利夫
• 通讯作者: 福里利夫

Enhanced expression of cox2 and cyp1A1 in early active lesions developed in offspring of rhesus monkeys with exposure to 2,3,7,8-tetrachlorobenzo-p-dioxin (TCDD) during gestation and lactation

妊娠期和哺乳期接触 2,3,7,8-四氯苯并二恶英 (TCDD) 的恒河猴后代早期活动性病变中 cox2 和 cyp1A1 的表达增强

• 发表时间: 2012
• 期刊: Organohalogen Compounds
• 作者: Toshio Fukusato;Masato Watanabe,Shunichiro Kubota;Akihiro Arima;Atsunobu Muneoka;Hiroshi Sumida;Mineo Yasuda;Onouchi H;Toshio Fukusato
• 通讯作者: Toshio Fukusato