The control strategy of stress-induced UCP2 expression and ROS generation in diabetes mellitus

糖尿病应激诱导的UCP2表达和ROS生成的控制策略

• 批准号: 22500767
• 负责人: MINAMIYAMA Yukiko
• 金额: $ 2.83万
• 依托单位: Kyoto Prefectural University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22500767/
• 关键词: 生活習慣病; ミトコンドリア機能; 低鉄; 抗酸化物質; 食事制限; UCP2; ミトコンドリア機能障害; 二型糖尿病; 酸化ストレス

It was found that the enhancement of oxidative stress by mitochondrial dysfunction and over-expression of UCP2 that negatively regulates reactive oxygen species (ROS) from mitochondria in diabetes mellitus.Calorie restrictions improved the diabetic complications.Furthermore, we found that iron deposition due to abnormal iron metabolism in diabetic tissues.It has been clear that the removal of iron therapy is effective in the treatment of diabetes. Thus, phlebotomy treatments currently being conducted in chronic hepatitis C treatment can be expected as an effective treatmentas an applicationto diabetes, in developing countries, particularly. In addition, antioxidants are also effective. S-allyl cysteine that is an antioxidantcomponent of the aged garliccould improve diabetic condition by controlling the mechanisms related to lipid metabolism and glucose metabolism.

研究发现，线粒体功能障碍和 UCP2 过度表达会增强氧化应激，从而对糖尿病中线粒体的活性氧 (ROS) 产生负调节。热量限制改善了糖尿病并发症。此外，我们发现异常的铁沉积糖尿病组织中的铁代谢。已经明确，去除铁疗法对于治疗糖尿病是有效的。因此，目前在慢性丙型肝炎治疗中进行的静脉切开术治疗有望作为糖尿病的有效治疗方法，特别是在发展中国家。此外，抗氧化剂也有效。 S-烯丙基半胱氨酸是陈蒜中的一种抗氧化成分，可以通过控制与脂质代谢和葡萄糖代谢相关的机制来改善糖尿病状况。

项目成果

Effects of aging on sperm function and oxidative stress.

衰老对精子功能和氧化应激的影响。

• 发表时间: 2010
• 作者: Y. Minamiyama;H. Ichikawa;TakemuraS;T. Kawagishi;A. Wakahara;C. Minami;M. Yasui;R. Yamamoto;NaitoY;T. Yoshikawa
• 通讯作者: T. Yoshikawa

Calorie restriction improves endothelial nitric oxide synthase overexpression and production of mitochondrial reactive oxygen species of cardiovasculatures in type II diabetic rats

热量限制改善 II 型糖尿病大鼠心血管系统内皮一氧化氮合酶的过度表达和线粒体活性氧的产生

• 发表时间: 2010
• 作者: Yukiko Minamiyama;Shigekazu Takemura;Hiroshi Ichikawa;Shintaro Kodai;Hiroji Shinkawa;Yuji Naito;Shigeru Okada;Toshikazu Yoshikawa.
• 通讯作者: Toshikazu Yoshikawa.

The role of histidine on wound healing using cultured rat intestinal epithelial cells.

使用培养的大鼠肠上皮细胞观察组氨酸对伤口愈合的作用。

• 发表时间: 2011
• 作者: K. Hori;H. Ichikawa,T. Takagi;Y. Minamiyama;M. Nakamura;A. Doi;Y. Kawabata;T. Kaneda;K. Uchiyama;Y. Naito;T. Yoshikawa
• 通讯作者: T. Yoshikawa

Generation of reactive oxygen species from the sperm mitochondria of rats is an excellent marker for the biological toxicity of endocrine-disrupting chemicals

大鼠精子线粒体产生的活性氧是内分泌干扰化学物质生物毒性的极好标志

• 发表时间: 2011
• 作者: Miyanishi E;Minamiyama Y;Ichikawa H;Takagi T;Ishii A;Handa O;Naito Y;Yoshikawa T
• 通讯作者: Yoshikawa T

Sperm dysfunction from aging is involved in the oxidative stress.

衰老导致的精子功能障碍与氧化应激有关。

• 发表时间: 2011
• 作者: R. Yamamoto;Y. Minamiyama;H. Ichikawa;T. Takagi;A. Ishii;Y. Sato;E. Miyanishi;M. Yasui;O. Handa;Y. Naito;T. Yoshikawa
• 通讯作者: T. Yoshikawa