Immunogenetic analysis of early onset schistosomal fibrosis in the Philippines

菲律宾早发血吸虫纤维化的免疫遗传学分析

• 批准号: 22406009
• 负责人: KIKUCHI Mihoko
• 金额: $ 12.4万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22406009/
• 关键词: 日本住血吸虫; フィリピン; 肝線維化症; 免疫応答性; 遺伝解析; HLA-DRB1*1501; mRNA; 若年性肝線維化症; 免疫応答; 国際研究者交流; 若年性; 住血吸虫中卵抗原; 宿主遺伝要因; 組織適合抗原(HLA)

Post-schistosomal hepatic fibrosis and cirrhosis are the major sequelae resulting from excessive immune response to deposited eggs in the portal area. In humans little is known about immunoregulatory mechanisms controlling the development of hepatosplenic disease. The objective of the study is to determine the prevalence of the early onset schistosomal fibrosis and the different host genetic factors and mechanism behind the immune responses in patients with early onset schistosomal liver fibrosis in the Sorsogon Province, Philippines. The subjects were subjected to Kato-katz stool examination, ultrasonographic examination, and detection of anti-SEA antibody, located in the schistosomiasis endemic barangays of the municipality of Irosin, in the province of Sorsogon. Results of imuunogenetical analysis showed measure immune-responses in early onset post schistosomal fibrosis was restricted HLA-DRB1*15:01 and progression was related on expression level of HLA-DRB1 gene.

血吸虫后肝纤维化和肝硬化是汇管区沉积虫卵过度免疫反应导致的主要后遗症。在人类中，人们对控制肝脾疾病发展的免疫调节机制知之甚少。该研究的目的是确定菲律宾索索贡省早发性血吸虫性纤维化的患病率以及早发性血吸虫性肝纤维化患者的不同宿主遗传因素和免疫反应背后的机制。对受试者进行了 Kato-katz 粪便检查、超声检查和抗 SEA 抗体检测，地点位于索索贡省伊罗辛市血吸虫病流行村。免疫遗传学分析结果显示，血吸虫后纤维化早期发病时的免疫反应受到HLA-DRB1*15:01的限制，且进展与HLA-DRB1基因的表达水平相关。

项目成果

Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins

菲律宾索索贡省血吸虫纤维化调查

• 发表时间: 2012
• 作者: 山口類;新川武;宮田健;原國哲也;田福宣治;只野昌之;菊池三穂子他
• 通讯作者: 菊池三穂子他

感染症事典

传染病百科全书

• 发表时间: 2011
• 作者: Takano;A.;Sugimori;C.;Fujita;H.;Kadosaka;T.;Taylor;K.R.;Tsubota;T.;Konnai;S.;Tajima;T.;Sato;K.;Watanabe;H.;Ohnishi;M.;Kawabata;H.;下川周子・濱野真二郎
• 通讯作者: 下川周子・濱野真二郎

Use of Cell-Free Circulating Schistosome DNA in Serum, Urine, Semen, and Saliva To Monitor a Case of Refractory Imported Schistosomiasis Hematobia

• DOI: 10.1128/jcm.01219-13
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF CLINICAL MICROBIOLOGY
• 影响因子: 9.4
• 作者: Kato-Hayashi, Naoko;Yasuda, Mitsuko;Chigusa, Yuichi
• 通讯作者: Chigusa, Yuichi

Origin of novel protein-coding genes with similar signal sequence in Schistosoma japonicum

日本血吸虫中具有相似信号序列的新型蛋白质编码基因的起源

• 发表时间: 2012
• 作者: Evaristus CM;Kikuchi M.;et al.
• 通讯作者: et al.

Detection of active schistosome infection by cell-free circulating DNA of Schistosoma japonicum in highly endemic areas in Sorsogon Province, the Philippines

• DOI: 10.1016/j.actatropica.2014.05.003
• 发表时间: 2015-01-01
• 期刊: ACTA TROPICA
• 影响因子: 2.7
• 作者: Kato-Hayashi, Naoko;Leonardo, Lydia R.;Chigusa, Yuichi
• 通讯作者: Chigusa, Yuichi