Resolution of the signaling networks involved in the pulp cell differentiation and its clinical application

牙髓细胞分化相关信号网络的解析及其临床应用

• 批准号: 22390357
• 负责人: KAWASHIMA Nobuyuki
• 金额: $ 10.82万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390357/
• 关键词: 歯髄; 歯髄細胞; 象牙芽細胞; Notch; Periostin; 細胞分化; シグナルネットワーク; 分化制御; 分化促進; 転写調節因子; 分化誘導; Hey1; 分化; 石灰化; Sp7

Losing the tooth vitality correlates to the tooth loss, this is a challenge to QOL. Strategies to keep the integrity of the pulp tissue and regenerate the new pulp tissue are hot topics. We have reported that Notch signaling is essential for differentiation of dental pulp cells. In this project, we revealed that a secretory protein, Periostin, regulated negatively the dental pulp cell differentiation into odontoblasts via notch signaling. Controlling the synthesis and production Periostin may be essential to induce the non-mineralized pulp tissue covered by the newly formed mineralized dentin.

牙齿活力的丧失与牙齿脱落相关，这是对生活质量的挑战。保持牙髓组织完整性和再生新牙髓组织的策略是热门话题。我们报道了Notch信号对于牙髓细胞的分化至关重要。在这个项目中，我们揭示了一种分泌蛋白 Periostin 通过缺口信号传导负向调节牙髓细胞分化为成牙本质细胞。控制骨膜素的合成和产生对于诱导新形成的矿化牙本质覆盖非矿化牙髓组织可能至关重要。

项目成果

Kinetics of Th17-related cytokine expression in experimentally induced rat periapical lesions

实验诱导的大鼠根尖周病变中 Th17 相关细胞因子表达的动力学

• DOI: 10.1111/j.1747-4477.2012.00371.x
• 发表时间: 2012
• 期刊: Aust Endod J
• 影响因子: 1.6
• 作者: S Wei;N Kawashima;N Suzuki;J Xu;S Takahashi;M Zhou;Y Koizumi;H Suda
• 通讯作者: H Suda

Mechanisms of Bone Destruction in the Periapical Lesions and Its Regulation

根尖周病变骨质破坏机制及其调控

• 发表时间: 2011
• 作者: Kawashima N;Suzuki N;Suda H
• 通讯作者: Suda H

単層培養法と三次元培養法における歯髄細胞の象牙芽細胞分化について

关于单层培养法和三维培养法中牙髓细胞的成牙本质细胞分化

• 发表时间: 2011
• 作者: 山本弥生子;川島伸之;須田英明
• 通讯作者: 須田英明

Mineralization of Odonotoblastic-Lineage Cells Was Accelerated by Enhanced Expression of Mef2c

Mef2c 表达的增强加速了成牙本质细胞谱系细胞的矿化

• 发表时间: 2011
• 作者: N Kawashima;J Xu;N Suzuki;M Zhou;K Takimoto;Y Koizumi;M Yamamoto;S Takahashi;T Sugiyama;H Suda
• 通讯作者: H Suda

Shh Signaling is Related to BMP and Wnt Signaling in Ameloblast Diff exentiation

Shh 信号与成釉细胞差异表达中的 BMP 和 Wnt 信号相关

• 发表时间: 2010
• 作者: S Takahashi;N Kawashima;K Katsube;T Sugiyama;H Sida
• 通讯作者: H Sida