Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases

氧甾醇酯诱导的内质应激及其疾病意义的研究

• 批准号: 22390187
• 负责人: ISHIBASHI Shun
• 金额: $ 12.06万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390187/
• 关键词: 小胞体ストレス; 細胞死; マクロファージ; コレステロール; オキシステロール; 脂質代謝異常; ERストレス; NCEH1; アポトーシス; ACAT

NCEH1、an microsomal protein which hydrolizes cholesterol ester (CE), mediates the hydrolysis of esterified form of 25-hydroxycholesterol (25-HC), one of oxysterols. In human monocyte-derived macrophages, NCEH1 is responsible for the CE hydrolysis. Absence

NCEH1 是一种水解胆固醇酯 (CE) 的微粒体蛋白，介导 25-羟基胆固醇 (25-HC) 的酯化形式的水解，在人单核细胞来源的巨噬细胞中，NCEH1 负责 CE 水解。

项目成果

In vivo efficacy of PRD017, a new pyripyropene A derivative and highly potent ACAT2-selective inhibitor, in apolipoprotein E KO mice

PRD017（一种新型吡啶平 A 衍生物和高效 ACAT2 选择性抑制剂）在载脂蛋白 E KO 小鼠中的体内功效

• 作者: 豊田健太郎;稲垣暢也;曽根三郎;Ohshiro T
• 通讯作者: Ohshiro T

Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement

• DOI: 10.1016/j.bbrc.2010.11.103
• 发表时间: 2011-01-07
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Ohta, Keisuke;Sekiya, Motohiro;Osuga, Jun-ichi
• 通讯作者: Osuga, Jun-ichi

The Critical Role of Neutral Cholesterol Ester Hydrolase 1 in Cholesterol Removal From Human Macrophages

• DOI: 10.1161/circresaha.110.226613
• 发表时间: 2010-11-26
• 期刊: CIRCULATION RESEARCH
• 影响因子: 20.1
• 作者: Igarashi, Masaki;Osuga, Jun-ichi;Ishibashi, Shun
• 通讯作者: Ishibashi, Shun

Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice

• DOI: 10.1016/j.bbrc.2012.02.117
• 发表时间: 2012-03-30
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Usui, Fumitake;Kimura, Hiroaki;Takahashi, Masafumi
• 通讯作者: Takahashi, Masafumi

Marked inhibition of atherosclerosis in mice lacking HMG-CoA reductase in a macrophage-specific manner

以巨噬细胞特异性方式显着抑制缺乏 HMG-CoA 还原酶的小鼠的动脉粥样硬化

• 作者: 小泉健三;清水利彦;鈴木則宏;Tumenbayar B
• 通讯作者: Tumenbayar B