RNA Biology for Stress Assessment and Prediction of Major Depression

RNA 生物学用于压力评估和重度抑郁症预测

• 批准号: 22390146
• 负责人: ROKUTAN Kazuhito
• 金额: $ 11.98万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390146/
• 关键词: ストレス; うつ病; 遺伝子発現; RNAマーカー; マイクロRNA; ストレス; うつ病; 遺伝子発現; RNAマーカー; マイクロRNA

This research project was designed to identify novel RNA markers for stress assessment and prediction of major depressive disorders. We reported acute stress-specific alternative splicing of SMG-1in peripheral blood (Neurosci Lett 2010) and chronic stress-specific reduction of a GR-beta isoform (Stress 2011). We also investigated stress-responsive microRNAs (miRNAs) in peripheral blood. We reported miR-16, miR-144, and miR144* as acute stress-responsive miRNAs (nuerosci Lett 2012).We also identified 7 miRNAs as chronic stress-responsive miRNAs.

该研究项目旨在确定新的RNA标记，以评估重力抑郁症。我们报道了SMG-1IN外周血（Neurosci Lett 2010）和慢性应激特异性降低GR-β同工型的急性应激特异性剪接（压力2011）。我们还研究了外周血中的应激响应性microRNA（miRNA）。我们报道了miR-16，miR-144和miR144*作为急性应激响应性miRNA（Nuerosci Lett 2012）。我们还将7个miRNA确定为慢性应激反应miRNA。