The physiological polymorphism of atherosclerosis investigated by genetic and environmental factors

遗传和环境因素研究动脉粥样硬化的生理多态性

基本信息

批准号：
22370090
负责人：
MAEDA Takahiro
金额：
$ 12.48万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010 至 2012
项目状态：
已结题

项目摘要

Most cases of atherosclerosis result from the interactions of multiple genetic and environmental factors. To investigate the association between gene polymorphisms and clinical parameter of atherosclerosis such as carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI), we conducted cross-sectional study of 1,295 Japanese (502 men and 793 women) who participated in a general health check in western rural community of the Goto Islands from 2000 to 2012. We analyzed polymorphisms of four genes such as MTHFR(rs1801133), HDAC4(rs3791398), CARKL(rs465563), and Adiponectin(rs1501299) which were reported the significant relation with atherosclerosis.The genotype distributions of four genes were as follows, MTHFR (CC: 43.2%, CT: 46.5%and TT: 10.3%), Adiponectin(GG: 53.7%, GT: 38.9%, and TT: 7.4%), HDAC4(GG: 80.4%, GA: 18.5%, and AA: 1.1%), and CARKL(GG: 12.7%, GA: 44.5%, and AA: 42.8%). No significant association between genotype and CAVI nor CIMT was observed. Next, we categorized into five groups based on the number of risky genotype and analyzed the association according to a group. Although no significant association was observed both in CIMT and CAVI, positive tendency was observed in CAVI. Further investigation with large number of participants is necessary to clarify the association between gene polymorphism and atherosclerosis.

大多数动脉粥样硬化病例是由多种遗传和环境因素的相互作用引起的。为了研究基因多态性与动脉粥样硬化的临床参数（例如颈动脉内膜厚度（CIMT）和心脏抑制血管指数（CAVI）），我们进行了1,295个日本人（502名男性和793名女性）的横断面研究，他们参与了西方国家的一般性检查，我们与2000年进行了分析，我们对2000年进行了分析。在四个基因（RS1801133），HDAC4（RS3791398），CARKL（RS465563）和脂联素（RS1501299）等四个基因中，报告了与动脉粥样硬化的显着关系。 TT：10.3％），脂联素（GG：53.7％，GT：38.9％和TT：7.4％），HDAC4（GG：80.4％，GA：GA：18.5％和AA：1.1％）和CARKL（GG：GG：12.7％，GA：GA：44.5％和AA：44.5％和AA：42.82.8％）。没有观察到基因型与Cavi或CIMT之间的显着关联。接下来，我们根据风险基因型的数量将五组分为五组，并根据一个组分析了该关联。尽管在CIMT和CAVI中未观察到显着关联，但在Cavi中观察到了阳性趋势。需要对大量参与者进行进一步研究，以阐明基因多态性和动脉粥样硬化之间的关联。