Establishment of a genetic diagnosis system for cancer predispositionand its application to cancer prevention.

癌症易感基因诊断体系的建立及其在癌症预防中的应用

• 批准号: 22300346
• 负责人: SHIMIZU Kenji
• 金额: $ 10.98万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300346/
• 关键词: 癌発症危険度; 癌体質遺伝; 遺伝的多型; リスク遺伝子型重複; 癌の早期発見; コホート研究; ミスセンス１塩基多型; ミスセンス1塩基多型; EGF受容体遺伝子変異; 癌分子疫学; 癌の早期発見診断

We have aimed to clarify the nature of genetic predisposition for sporadic cancers, influenced by genetic polymorphisms, such as single-nucleotide polymorphism (SNP). By analyzing about 8,000 specimens, we found 53 SNP are related with at least one of 17 major cancers in Japan. Stratification of the data of the multiplied OR of overlapping SNP for each cancer and each individual revealed that about 15% and 1% of the Japanese represent the high- and the highest risk-group for most cancers, respectively. Other major findings are, about half of the SNPs at risk were replicated between two case/control data sets on 4 kinds of cancers, Risk-SNP combinations were largely different between genders, some SNPs were identified as those closely associated with cancer-progression or occurrence of specific gene alterations.

我们的目的是阐明散发性癌症的遗传易感性的本质，其受到遗传多态性（例如单核苷酸多态性（SNP））的影响。通过分析约 8,000 个样本，我们发现 53 个 SNP 与日本 17 种主要癌症中的至少一种相关。对每种癌症和每个人的重叠 SNP 的乘积 OR 数据进行分层显示，约 15% 和 1% 的日本人分别代表大多数癌症的高风险群体和最高风险群体。其他主要发现是，大约一半的风险 SNP 在 4 种癌症的两个病例/对照数据集之间重复，风险-SNP 组合在性别之间存在很大差异，一些 SNP 被确定为与癌症进展或癌症密切相关的 SNP。特定基因改变的发生。

项目成果

Proteomics-based analysis of invasion-related proteins in malignant gliomas.

• DOI: 10.1111/j.1440-1789.2012.01361.x
• 发表时间: 2013-06
• 期刊: Neuropathology : official journal of the Japanese Society of Neuropathology
• 作者: Maruo T;Ichikawa T;Kanzaki H;Inoue S;Kurozumi K;Onishi M;Yoshida K;Kambara H;Ouchida M;Shimizu K;Tamaru S;Chiocca EA;Date I
• 通讯作者: Date I

Expression Change of Neuraglin 1 is Preferentially Associated with Neuropethic Pain.

Neuraglin 1 的表达变化优先与神经疼痛相关。

• 发表时间: 2010
• 作者: Hirochika Nakajima;ほか
• 通讯作者: ほか

Identification of true targets of MicroRNA-183 in lung cancer cells using labeled ds-miRNA in vitro pull-down assay

使用标记的 ds-miRNA 体外 Pull-down 测定鉴定肺癌细胞中 MicroRNA-183 的真正靶标

• 发表时间: 2010
• 作者: Ito S;Hanafusa H;Ouchida M;ShimizuK.
• 通讯作者: ShimizuK.

Comprehensive SNP Analyses on Genetic Predisposition for lncidence of 14 Major Cancers in Japan.

日本 14 种主要癌症发病遗传倾向的综合 SNP 分析。

• 发表时间: 2010
• 作者: Rella S. F.;Tada R.;Nakashima K.;Ikehara M.;Itaki T.;Ohkushi K.;Sakamoto T.;Harada N.;Uchida M;Kenji Shimizu
• 通讯作者: Kenji Shimizu

乳癌におけるmiR-17-92 cluster の新規標的タンパク質の検討

乳腺癌中 miR-17-92 簇新靶蛋白的检查

• 发表时间: 2012
• 作者: 宮崎真;萬和明;浅沼順;近藤雅征;大内田守
• 通讯作者: 大内田守