Development of magnetic and optical nanodiamond implanted with paramagnetic ions

植入顺磁性离子的磁性和光学纳米金刚石的开发

• 批准号: 21700465
• 负责人: MORITA Masahito
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700465/
• 关键词: ナノバイオロジー; ナノメディスン; マルチモーダル造影剤; 低侵襲医療; ナノダイヤモンド; MRI; イオン注入; 金ナノ粒子

We succeeded in the synthesis of multimodal nanodiamond responded to the magnetic field and visible light. The attachment of gold nanoparticles on the multimodal nanodiamond resulted in the stable disperse in a physiological condition. A mouse liver was visualized 6 and 24 hours later after the administration of this PEG-Au-Mn-ND into mouse tail vein. Further TEM analysis revealed that these hybrid nanomaterials were distributed in liver tissue including Kupper cells. These results imply that the paramagnetic-ion implanted nanodimoand have the potential to be used for long-term in vivo imaging experiments, including cell tracking, metabolic change etc. in the future.

我们成功地合成了多模式纳米座原子，对磁场和可见光做出了反应。金纳米颗粒在多模式纳米座上的附着导致稳定的分散在生理状态。在将PEG-AU-MN-ND施用到小鼠尾静脉后6和24小时后，将小鼠肝脏可视化。进一步的TEM分析表明，这些杂交纳米材料分布在包括库珀细胞在内的肝组织中。这些结果表明，顺磁性离子植入的纳米型具有可能用于长期体内成像实验的潜力，包括将来，包括细胞跟踪，代谢变化等。

项目成果

分子・細胞イメージングのためのマルチモーダルイメージング技術

用于分子和细胞成像的多模态成像技术

• 发表时间: 2009
• 作者: Yamaoka Y;Nambu M;Takamatsu T;T.Okumura;森田将史
• 通讯作者: 森田将史

Preparation for highly sensitive MRI contrast agents using core/shell type nanoparticles consisting of multiple SPIO cores with thin silica coating.

• DOI: 10.1021/la1015077
• 发表时间: 2010-06
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: Kazuo Tanaka;Asako Narita;Narufumi Kitamura;Wataru Uchiyama;Masahito Morita;T. Inubushi;Y. Chujo

Mn doped magnetic nanodiamond for MRI imaging probes

用于 MRI 成像探针的锰掺杂磁性纳米金刚石

• 发表时间: 2010
• 作者: Yamaoka Y;Nambu M;Takamatsu T;N.Sakamoto;Morita M
• 通讯作者: Morita M

MRI and MRS for visualization of immune responses、"Frontier Immuno-Imaging"

用于免疫反应可视化的 MRI 和 MRS，“前沿免疫成像”

• 发表时间: 2009
• 作者: Morita M

Simple PEG Conjugation of SPIO via an Au-S Bond Improves Its Tumor Targeting Potency as a Novel MR Tumor Imaging Agent

通过 Au-S 键对 SPIO 进行简单的 PEG 共轭，提高其作为新型磁共振肿瘤成像剂的肿瘤靶向效力

• DOI: 10.1021/bc900487p
• 发表时间: 2010-06-01
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Kojima, Hiroki;Mukai, Yohei;Nakagawa, Shinsaku
• 通讯作者: Nakagawa, Shinsaku