Changes of excitability to mechanical stretch in bladder smooth muscle and its effect to OAB.

膀胱平滑肌机械拉伸兴奋性的变化及其对OAB的影响。

• 批准号: 21791521
• 负责人: YANAI Yoshimasa
• 金额: $ 2.5万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791521/
• 关键词: 膀胱平滑筋; 進展刺激; 細胞内電位記録; 過活動膀胱; 活動電位

We have examined physiological functions of smooth muscles using a technique of intracellular membrane potential recording, intracellular Ca2+ concentration recording. In this time, we aimed to study the changes of excitability caused by time-dependent change of mechanical stretch in the bladder smooth muscle. Although the frequency of spontaneous action potentials seemed to be increased when the smooth muscle was stretched gradually, it was very difficult to record continuously in spite of stretching.We will continue to study to understand the effect of mechanical stretch recording spontaneous contractions of smooth muscle strips.

我们已经使用细胞内膜电位记录的技术，细胞内Ca2+浓度记录检查了平滑肌的生理功能。在这段时间里，我们旨在研究膀胱平滑肌中机械拉伸的时间变化引起的兴奋性变化。尽管当平滑肌逐渐拉伸时，自发动作电位的频率似乎增加了，但尽管有拉伸，但仍很难连续记录。我们将继续研究以了解机械拉伸记录平滑肌条的自发收缩的影响。

项目成果

膀胱排尿筋収縮とNO

膀胱逼尿肌收缩和NO

• 发表时间: 2010
• 期刊: 排尿障害プラクティス Vol.18 No.2
• 作者: 矢内良昌;佐々木昌一;窪田泰江;橋谷光;郡健二郎
• 通讯作者: 郡健二郎