Role of inhibitory signal factors in osteoclastogenesis

抑制信号因子在破骨细胞生成中的作用

• 批准号: 21791411
• 负责人: HIKATA Tomohiro
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791411/
• 关键词: 骨; 軟骨代謝学; PIAS3; PIAS1; 破骨細胞; PIAS; SUMO; E3 ligase

Osteoclasts are unique bone-resorbing cells, and that loss of osteoclast differentiation or function results in defect of bone homeostasis. Thus regulation of osteoclastogenesis is crucial to maintain bone homeostasis. Osteoclast differentiation is regulated in a delicate balance between positive and negative regulators, however, the precise mechanism is still unclear. In this study, we characterized the inhibitory roles of PIAS1 in osteoclast differentiation.

破骨细胞是独特的骨质细胞，破骨细胞分化或功能的丧失导致骨稳态缺陷。因此，调节破骨细胞生成对于维持骨稳态至关重要。整骨细胞的分化在正调节剂和负调节剂之间的微妙平衡中受到调节，但是，确切的机制尚不清楚。在这项研究中，我们表征了PIAS1在破骨细胞分化中的抑制作用。

项目成果

Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages.

NF-kappaB (RANK) 配体的受体激活剂诱导小鼠 RAW264.7 巨噬细胞中 RANK 的胞外域脱落。

• 发表时间: 2010
• 期刊: J Immunol. 184
• 作者: Hakozaki A;Yoda M;Tohmonda T;Furukawa M;Hikata T;Uchikawa S;Takaishi H;Matsumoto M;Chiba K;Horiuchi K;Toyama Y.
• 通讯作者: Toyama Y.

IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos.

IL-27 通过 STAT1 依赖性 c-Fos 抑制，消除 NF-κ B 配体介导的人粒细胞-巨噬细胞集落形成单位细胞破骨细胞生成的受体激活剂。

• 发表时间: 2009
• 期刊: J Immunol. 183
• 作者: Furukawa M;Takaishi H;Takito J;Yoda M;Sakai S;Hikata T;Hakozaki A;Uchikawa S;Matsumoto M;Chiba K;Kimura T;Okada Y;Matsuo K;Yoshida H;Toyama Y.
• 通讯作者: Toyama Y.

A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.

• DOI: 10.1016/j.devcel.2009.10.011
• 发表时间: 2009-12
• 期刊: Developmental cell
• 影响因子: 11.8
• 作者: Yokoyama S;Ito Y;Ueno-Kudoh H;Shimizu H;Uchibe K;Albini S;Mitsuoka K;Miyaki S;Kiso M;Nagai A;Hikata T;Osada T;Fukuda N;Yamashita S;Harada D;Mezzano V;Kasai M;Puri PL;Hayashizaki Y;Okado H;Hashimoto M;Asahara H
• 通讯作者: Asahara H

IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos

IL-27 通过 STAT1 依赖性抑制 c-Fos 消除 NF-κ B 配体介导的人粒细胞-巨噬细胞集落形成单位细胞破骨细胞生成的受体激活剂

• 发表时间: 2009
• 期刊: Endocrinology 183
• 作者: Ota N;Takaishi H;Kosaki N;Takito J;Yoda M;Tohmonda T;Kimura T;Okada Y;Yasuda H;Kawaguchi H;Matsumoto M;Furukawa M;Takaishi H;Takito J;Yoda M;Sakai S;Hikata T;Hakozaki A;Uchikawa S;Matsumoto M;Chiba K;Kimura T;Okada Y;Matsuo K;Yoshi
• 通讯作者: Yoshi

Receptor activator of NF-kappaB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages

NF-κB (RANK) 配体的受体激活剂诱导小鼠 RAW264.7 巨噬细胞中 RANK 的胞外域脱落

• 发表时间: 2010
• 期刊: J Immunol. 184
• 作者: Hakozaki A;Yoda M;Tohmonda T;Furukawa M;Hikata T;Uchikawa S;Takaishi H;Matsumoto M;Chiba K;Horiuchi K;Toyama Y
• 通讯作者: Toyama Y