Bio-absorbable material for reconstruction of the rotator cuff defect

用于重建肩袖缺损的生物可吸收材料

• 批准号: 13680945
• 负责人: AOKI Mitsuhiro
• 金额: $ 2.05万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680945/
• 关键词: Bio-absorbable materials; Poly-L-lactic acid felt; Culture; Transplantation; Hydrolysis; Reconstruction of rotator cuff; Enthesis; Tensile strength; テフロンフェルト; PDSテープ; 機械特性; 組織反応

Poly(L-lactic acid) felt (PLLA felt) was prepared in an attempt to reconstruct the rotator cuff in beagle dogs. Little change was found on the tensile strength of both the cultured PLLA felt and the PLLA felt implanted on the para-vertebral muscle of rabbits up to 12 weeks, although the stiffness of the felt implanted on the muscle of 6 weeks showed a statistically significant increase. When the infraspinatus tendons of beagle dog were reconstructed with the PLLA felt, the ultimate strength of PLLA felt increased 3 times and the stiffness increased 5 times at 16postoperative weeks compared to that of the PLLA felt. They were statistically significant (p<0.01). All the implanted specimens ruptured at the junction between the bone and the PLLA felt. Histological examination demonstrated infiltration of fibrous tissue into the interstices of the PLLA felt fibers. Connection between the infraspinatus tendon and the PLLA felt was tight under formation of scar tissue, but the connective tissue between the bone and PLLA felt fibers was sparse even at 16 and 32 postoperative weeks. A few deteriorated PLLA felt fibers were observed at 32 postoperative weeks. Although the degradation rate of PLLA felt was very low, the PLLA felt was found to be useful for rotator cuff reconstruction.

制备聚（L-乳酸）毛毡（PLLA毛毡）是为了尝试重建比格犬的肩袖。培养的 PLLA 毛毡和植入兔椎旁肌的 PLLA 毛毡在 12 周内的拉伸强度几乎没有变化，尽管植入肌肉的 PLLA 毛毡在 6 周时的刚度显示出统计上显着的增加。用PLLA毡重建Beagle犬冈下肌腱后，术后16周PLLA毡的极限强度比PLLA毡提高了3倍，刚度提高了5倍。它们具有统计学意义（p<0.01）。所有植入的样本均在骨头和 PLLA 毛毡之间的交界处破裂。组织学检查表明纤维组织浸润到 PLLA 毡纤维的间隙中。冈下肌腱和 PLLA 毡之间的连接在疤痕组织形成下紧密，但骨和 PLLA 毡纤维之间的结缔组织即使在术后 16 和 32 周也很稀疏。术后 32 周观察到一些 PLLA 毛毡纤维劣化。尽管 PLLA 毛毡的降解率非常低，但人们发现 PLLA 毛毡对于肩袖重建很有用。

项目成果

青木光広ほか: "腱板縫合および再建術の縫合部機械特性"北海道リハビリ. 30. 49-54 (2002)

Mitsuhiro Aoki 等：“肩袖缝合和重建的机械特性”北海道康复。 30. 49-54 (2002)。

Kagaya K, et al: "Initial strength of repaired rotator cuff : immediate repair and delayed repair"Shoulder Joint. 26, (Japanese). 203-206 (2002)

Kagaya K 等人：“修复肩袖的初始强度：立即修复和延迟修复”肩关节。

Oguma H, et al.: "Early anchoring collagen fibers at the bone-tendon interface are conducted by woven bone formation : light microscope and scanning electron microscope observation using a canine model"J Orthop Res. 19. 873-880 (2001)

Oguma H 等人：“骨-肌腱界面处的早期锚定胶原纤维是通过编织骨形成进行的：使用犬模型进行光学显微镜和扫描电子显微镜观察”J Orthop Res。

Aoki M, et al.: "Fibrous connection to bone after immediate repair of the canine infraspinatus : The most effective bony surface for tendon attachment"J Shoulder Elbow Surg. 10. 123-128 (2001)

Aoki M 等人：“犬冈下肌立即修复后与骨的纤维连接：肌腱附着最有效的骨表面”J Shoulder Elbow Surg。

加賀谷圭子ほか: "新鮮および凍結棘下筋腱の骨腱縫合部引張強度の回復"日本臨床バイオメカニクス学会誌. 23. 41-46 (2002)

Keiko Kagaya 等人：“新鲜和冷冻冈下肌腱骨腱缝合处拉伸强度的恢复”日本临床生物力学学会杂志 23. 41-46 (2002)。