Effects of Japanese Kanpo on gastrointestinal motility disorders in inflammatory bowel disease.

日本汉方对炎症性肠病胃肠动力障碍的影响。

• 批准号: 21790629
• 负责人: KITO Yoshihiko
• 金额: $ 2.75万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790629/
• 关键词: 東洋医学; 炎症性腸疾患; 漢方薬; 平滑筋; 自発活動; 結腸; カハールの介在細胞

Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) inhibited the generation of spontaneous contractions of circular muscles in the rat distal colon. The production of nitric oxide was partially involved in those inhibitory effects. TJ-14 also inhibited atropine-sensitive contractions induced by transmural nerve stimulation (TNS), suggesting that TJ-14 seems to be effective in severe diarrhea in ulcerative colitis or Crohn disease. On the other hand, TJ-60 showed weak inhibitory effect on atropine-sensitive contractions induced by TNS. Thus, TJ-60 may be effective in irritable bowel syndrome, which causes recurring diarrhea and/or constipation in association with abdominal pain.

Hange-shashin-to (TJ-14) 和 Keishi-ka-shakuyaku-to (TJ-60) 抑制大鼠远端结肠环形肌自发收缩的产生。一氧化氮的产生部分参与了这些抑制作用。 TJ-14 还抑制跨壁神经刺激 (TNS) 诱导的阿托品敏感收缩，表明 TJ-14 似乎对溃疡性结肠炎或克罗恩病的严重腹泻有效。另一方面，TJ-60对TNS诱导的阿托品敏感收缩表现出较弱的抑制作用。因此，TJ-60 可能对肠易激综合症有效，这种综合症会导致反复腹泻和/或便秘并伴有腹痛。

项目成果

Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus

• DOI: 10.1152/ajpgi.00118.2009
• 发表时间: 2009-10-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
• 影响因子: 4.5
• 作者: Kito, Yoshihiko;Sanders, Kenton M.;Suzuki, Hikaru
• 通讯作者: Suzuki, Hikaru