The effect of extracellular ATP on LPS-induced endotoxin shock in mice.

细胞外 ATP 对 LPS 诱导的小鼠内毒素休克的影响。

• 批准号: 21790381
• 负责人: KAWAMURA Hiroki
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790381/
• 关键词: マクロファージ; ATP; エンドトキシン; 好中球; MIP-2; LPS; IL-1β; エンドトキシンショック

Extracellular ATP leads to immune responses in a wide spectrum of cell types (e.g., macrophages, T cells) and tissues. However, it remains unclear whether such ATP-activated macrophages modulate the magnitude of immune responses to actual tissue injury. Thus, we investigated the role of ATP-mediated inflammatory response by macrophages in LPS-induced endotoxin shock. This study indicated that the binding of extracellular ATP to P2purinergic receptors on macrophages increases neutrophil infiltration via the production of MIP-2. However, in this pathway, further examination was required because P2purinergic receptor of the having many kinds was related.

细胞外ATP导致各种细胞类型（例如巨噬细胞，T细胞）和组织的免疫反应。但是，尚不清楚这种ATP激活的巨噬细胞是否调节了对实际组织损伤的免疫反应的大小。因此，我们研究了ATP介导的巨噬细胞在LPS诱导的内毒素休克中的炎症反应的作用。这项研究表明，细胞外ATP与巨噬细胞对P2Purin能受体的结合通过MIP-2的产生增加了中性粒细胞的浸润。但是，在此途径中，需要进一步检查，因为具有多种类型的P2Purin能受体。

项目成果

Extracellular ATP-activated NKT cells and macrophages aggravate Con A-induced liver iniury in mice

细胞外 ATP 激活的 NKT 细胞和巨噬细胞加重 Con A 诱导的小鼠肝损伤

• 发表时间: 2009
• 作者: Watanabe A.;Ogiwara H.;Ehata S.;Mukasa A.;Ishikawa S.;Maeda D.;Ueki K.;Ino Y.;Todo T.;Yamada Y.;Fukayama M.;Miyazono K.;Aburatani H.;川村宏樹
• 通讯作者: 川村宏樹

Extracellular ATP-activated NKT cells and macrophages aggravate Con A-induced liver injury in mice

细胞外 ATP 激活的 NKT 细胞和巨噬细胞加重 Con A 诱导的小鼠肝损伤

• 发表时间: 2009
• 作者: Komuro A;Yashiro M;Iwata C;Morishita Y;Johansson E;Matsumoto Y;Watanabe A;他;川村宏樹
• 通讯作者: 川村宏樹

Coincidence of autoantibody production with the activation of natural killer T cells in α-galactosylceramide-mediated hepatic injury

• DOI: 10.1111/j.1365-2567.2011.03405.x
• 发表时间: 2011-05-01
• 期刊: IMMUNOLOGY
• 影响因子: 6.4
• 作者: Matsumoto, Hiroaki;Kawamura, Toshihiko;Abo, Toru
• 通讯作者: Abo, Toru

Extracellular ATP-activated macrophages aggravate Con A-induced liver injury in mice

细胞外 ATP 激活的巨噬细胞加重 Con A 诱导的小鼠肝损伤

• 发表时间: 2010
• 作者: Seki M;Watanabe A;他;長尾朋和;川村宏樹
• 通讯作者: 川村宏樹