The Withdrawal of Immunosuppressive Regimen by CD15s monitoring

通过 CD15 监测取消免疫抑制方案

• 批准号: 13671258
• 负责人: ISHIDA Hideki
• 金额: $ 1.86万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671258/
• 关键词: CD15s; Immunosuppressive Regimen; Rejection; withdrawal; ステロイド; 寛容状態; 免疫抑制剤の投与中止; イヌの動物実験; ヒトの応用

In ABO incompatible renal transplantation, we experienced hyper acute rejection leading to graft loss. During this period, we observed the rapid elevation of CD15s Antigen with two high peaks. Double color flow cytometric analysis demonstrated that this high peak was activated plasma cells stained by CD10Ab. No performance of splenectomy was believed to activate memory B lymphocytes in recipient's spleen. We obtained the similar result in animal experiments. High expression of CD15s was observed with senu creatinine elevation after withdrawal of Immunosuppression.

在 ABO 血型不相容的肾移植中，我们经历了超急性排斥反应，导致移植物丢失。在此期间，我们观察到CD15s抗原快速升高，并出现两个高峰。双色流式细胞术分析表明该高峰是 CD10Ab 染色的活化浆细胞。据信，脾切除术不会激活受者脾脏中的记忆 B 淋巴细胞。我们在动物实验中也得到了类似的结果。停止免疫抑制后，随着血清肌酐升高，观察到 CD15 的高表达。

项目成果

Hideki ISHIDA: "Mycophenolate mofetil suppresses the production of anti-blood type antibodies after renal Tx across the ABO blood barrier"Transplantation. 74(8). 1187-1189 (2002)

Hideki ISHIDA：“吗替麦考酚酯抑制肾 Tx 跨越 ABO 血屏障后抗血型抗体的产生”移植。

Hideki Ishida, et al.: "CD15s monitoring as a means to select anti-rejection therapy in patients with rejection after renal transplantation"Transplantation. 69(10). 2208-2211 (2000)

Hideki Ishida 等人：“CD15s 监测作为肾移植后排斥反应患者选择抗排斥治疗的手段”移植。

ISHIDA H et al.: "Outcome of an ABO-incompatible renal transplant without splenectomy"Transplant Int. 15(1). 56-58 (2002)

ISHIDA H 等人：“未切除脾脏的 ABO 血型不相容肾移植的结果”Transplant Int.

Hideki ISHIDA: "Sialyl Lewisx as an early detector for B cell-dependent rejection"Transplant Proc. 34. 1760-1762 (2002)

Hideki ISHIDA：“Sialyl Lewisx 作为 B 细胞依赖性排斥的早期检测器”Transplant Proc。

Hideki Ishida, et al.: "Outcane of ABO incompatible renal transplant without splenectory"Transplant International. (in print). (2002)

Hideki Ishida 等人：“ABO 血型不相容肾移植不带脾脏的 Outcane”移植国际。