Sensing system to detect magnetic nano-particles for magnetic drug delivery

检测用于磁性药物输送的磁性纳米颗粒的传感系统

• 批准号: 21760313
• 负责人: HATSUKADE Yoshimi
• 金额: $ 2.83万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21760313/
• 关键词: 計測システム; ドラッグデリバリー; 磁気的ドラッグデリバリー; 磁気ナノ微粒子; 磁気センサ; SQUID; 薬剤検出; センサアレイ; 磁気特性; SUID

In this study, we developed a sensing system using ultra-sensitive SQUID magnetic sensors to detect magnetic nano-particles as a component technology for magnetic drug delivery system (MDDS). An array of 3 channel SQUID was installed on the system, to study the magnetic characteristics of magnetic nano-particles, whose diameters were less than 100 nm. An appropriate method to magnetize and detect the magnetic nano-particles was also investigated. As a result, we found that the particles with diameter of 50 nm generated the largest magnetic signal among the tested particles, and that a dc magnetization method was best suited because this method enabled to suppress energy due to the Brownian motion and convection in ferrofluid of 3 micron litter by means of the static magnetic field, and to detect moving particles in a tube.

在这项研究中，我们开发了一种传感系统，使用超灵敏 SQUID 磁传感器来检测磁性纳米颗粒，作为磁性药物输送系统 (MDDS) 的组件技术。系统上安装了3通道SQUID阵列，用于研究直径小于100 nm的磁性纳米颗粒的磁特性。还研究了磁化和检测磁性纳米颗粒的适当方法。结果，我们发现直径为 50 nm 的颗粒在测试颗粒中产生了最大的磁信号，并且直流磁化方法最适合，因为该方法能够抑制由于铁磁流体中的布朗运动和对流而产生的能量。借助静磁场检测3微米垃圾，并检测管中移动的颗粒。

项目成果

Biomagnetic Application using HTS-SQUID Array

使用 HTS-SQUID 阵列的生物磁应用

• 发表时间: 2010
• 作者: Y.Hatsukade;A.Karitani;M.Takemoto;T.Terui;Y.Kitamura;Y.Shinyama;S.Fukumoto;S.Tanaka
• 通讯作者: S.Tanaka

Liquid-State Nuclear Magnetic Resonance Measurements for Imaging using HTS-rf-SQUID in Ultra-Low Field

超低场中使用 HTS-rf-SQUID 进行液态核磁共振成像测量

• 发表时间: 2010
• 作者: S.Fukumoto;M.Hayashi;Y.Katsu;M.Suzuki;R.Morita;Y.Naganuma;Y.Hatsukade O.Snigirev;S.Tanaka
• 通讯作者: S.Tanaka

HTS-RF-SQUID Microscope For Metallic Contaminant Detection

用于金属污染物检测的 HTS-RF-SQUID 显微镜

• 发表时间: 2010
• 作者: M.Takemoto;T.Akai;Y.Kitamura;Y.Hatsukade;S.Tanaka
• 通讯作者: S.Tanaka

Determination of the robustness of an HTS SQUID magnetometer covered with a superconducting film shield in an ac field

确定覆盖有超导薄膜屏蔽的 HTS SQUID 磁力计在交流场中的鲁棒性

• 发表时间: 2009
• 期刊: Supercond.Sci.Technol. Vol.22
• 作者: Y.Hatsukade;K.Hayashi;M.Takemoto;S.Tanaka
• 通讯作者: S.Tanaka

Nondestructive evaluation of braided carbon fiber composites with artificial defect using HTS-SQUID gradiometer

• DOI: 10.1016/j.physc.2011.05.169
• 发表时间: 2011-11
• 期刊: Physica C-superconductivity and Its Applications
• 影响因子: 1.7
• 作者: Y. Shinyama;T. Yamaji;Y. Hatsukade;Y. Takai;M. Aly-Hassan;A. Nakai;H. Hamada;Saburo Tanaka