Structural evaluation of stratum corneum investigated by electron spin resonance imaging

通过电子自旋共振成像研究角质层的结构评估

• 批准号: 21500410
• 负责人: NAKAGAWA Kouichi
• 金额: $ 2.83万
• 依托单位: Hirosaki University (2010-2011)Fukushima Medical University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500410/
• 关键词: 生体情報; 計測; 生体計測; 電子スピン共鳴; 皮膚角層; ESRイメージング; スピンプローブ; シミュレーション; 皮膚角層脂質

Electron spin resonance (ESR) in conjunction with a slow-tumbling simulation was utilized for defining various stratum corneum (SC) lipid structures. The α-terpineol enhanced about three times permeation of the single chain 5-DSA than that of the control. We also studied psoriasis vulgaris SC (pv-SC). We found that the pv-SC is less ordering of the structure than that of the control SC, indicating abnormal architecture of the pv-sc.A 9 GHz ESR imager that is capable of the imaging surface area of thin materials has been built. More importantly, the TE111 cavity does not require inserting the sample into the cavity and placing samples into ESR tubes. In addition, the components of the 9 GHz imager and imaging data processing are developed.

与缓慢的模拟结合使用电子自旋共振（ESR）来定义各种角膜（SC）脂质结构。单链5-DSA的渗透量是对照的三倍。我们还研究了牛皮癣法拉利斯SC（PV-SC）。我们发现，PV-SC的结构比控制SC的排序较少，这表明PV-SC的异常结构是构建薄材料成像表面积的9 GHz ESR成像仪。更重要的是，TE111腔不需要将样品插入腔内并将样品放入ESR管中。此外，开发了9 GHz成像仪和成像数据处理的组件。

项目成果

EPR Investigations of Spin-Probe Dynamics in Aqueous Dispersions of a Nonionic Amphiphilic Compound

• DOI: 10.1007/s11746-008-1317-8
• 发表时间: 2009-01-01
• 期刊: JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
• 影响因子: 2
• 作者: Nakagawa, Kouichi

Structural Investigation of Stratum Corneum Lipid by Electron Paramagnetic Resonance

电子顺磁共振研究角质层脂质的结构

• 发表时间: 2010
• 作者: 高橋正信;中野雅行;Kouichi Nakagawa
• 通讯作者: Kouichi Nakagawa

重粒子線照射によるスクロースとL-アラニンラジカルの生成断面積の検討

通过重粒子束照射检查蔗糖和L-丙氨酸自由基生成的截面积

• 发表时间: 2010
• 作者: Miyamoto;Y.;Noda;Y.;Iida;T.;Yamaguchi;K.;Nishimura;S.;Tanaka;A.;Segawa;S.;and Inui;T.;中川公一,松本謙一郎
• 通讯作者: 中川公一,松本謙一郎

Stratum Corneum Lipid Structure Investigated by EPR Spin-Probe Method : Application of Terpenes

EPR旋转探针法研究角质层脂质结构：萜烯的应用

• DOI: 10.1007/s11745-010-3479-z
• 发表时间: 2010
• 期刊: Lipids
• 影响因子: 1.9
• 作者: 藤井智郁;山田耕輔;高橋正信;鈴木信雄;K. Nakagawa and K. Anzai
• 通讯作者: K. Nakagawa and K. Anzai

Structural Investigation of Stratum Corneum Lipid Using Electron Paramagnetic Resonance

利用电子顺磁共振研究角质层脂质的结构

• 发表时间: 2011
• 作者: K.Nakagawa;S.Hamakake
• 通讯作者: S.Hamakake