A New Hypothesis on Brain Sexual Differentiation and Regulation of Hormone Sensitivity by Local Brain Estrogen-Synthesis

关于大脑性别分化和局部大脑雌激素合成调节激素敏感性的新假设

• 批准号: 21500326
• 负责人: SHINODA Koh
• 金额: $ 2.75万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500326/
• 关键词: アンドロゲン受容体; エストロゲン受容体; HAP1; 内側視索前野; 分界条床核; 内側扁桃体; 海馬; アロマテース; stigmoid body; 脊髄小脳変性症

Sexually dimorphic expression of AR, ERα, and ERβwere immunohistochemically clarified in the medial preoptic and amygdaloid nuclei and hippocampus of male and female rats ; ERα-immunoreactive cells were identified as the SLH neurons in the hippocampus. The sex differences were primarily attributable to up-regulation of AR by androgen, down-regulation of ERαby estrogen and relatively stable ERβexperession in both sexes. It was suggested that HAP1/ STB is involved in regulation of nuclear translocation of AR, ERα, ERβand GR through its binding to their LBDs in each cDNA-transfected cultured cells.

通过免疫组织化学方法阐明了雄性和雌性大鼠内侧视前核和杏仁核以及海马中 AR、ERα 和 ERβ 的性别二态性表达；ERα 免疫反应细胞被鉴定为海马中的 SLH 神经元。雄激素对 AR 的调节，雌激素对 ERα 的下调以及 ERβ 表达相对稳定研究表明，HAP1/STB 通过与每个 cDNA 转染的培养细胞中的 LBD 结合，参与 AR、ERα、ERβ 和 GR 核转位的调节。

项目成果

斑点小体によるステロイド受容体のダイナミクス

斑点体类固醇受体的动力学

• 发表时间: 2011
• 作者: 岡達郎;横田茂文;津森登志子;牛建国;安井幸彦;森田晶子・宮田清司;篠田晃
• 通讯作者: 篠田晃

脳内エストロゲン合成と脳の性差形成

大脑中雌激素的合成以及大脑中性别差异的形成

• 发表时间: 2011
• 作者: Shibata S;Yasuda A;Renault-Mihara F;Suyama S;Katoh H;Inoue T;Inoue;YU;Nagoshi N;Sato M;Nakamura M;Akazawa C;Okano H.;森田晶子・中島敏博・宮田清司;神野尚三;篠田晃
• 通讯作者: 篠田晃

CHARACTERIZATION OF THE "SPORADICALLY LURKING HAP1-IMMUNOREACTIVE (SLH) CELLS" IN THE HIPPOCAMPUS, WITH SPECIAL REFERENCE TO THE EXPRESSION OF STEROID RECEPTORS, GABA, AND PROGENITOR CELL MARKERS

• DOI: 10.1016/j.neuroscience.2012.02.029
• 发表时间: 2012-05-17
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Islam, Md N.;Fujinaga, R.;Shinoda, K.
• 通讯作者: Shinoda, K.

Intracellular colocalization of HAP1/STBs with steroid hormone receptors and its enhancement by a proteasome inhibitor

• DOI: 10.1016/j.yexcr.2011.05.004
• 发表时间: 2011-07-15
• 期刊: EXPERIMENTAL CELL RESEARCH
• 影响因子: 3.7
• 作者: Fujinaga, Ryutaro;Takeshita, Yukio;Shinoda, Koh
• 通讯作者: Shinoda, Koh

物忘れと認知症

健忘和痴呆

• 发表时间: 2011
• 作者: Watanabe-Hosomi A;Watanabe Y;Tanaka M;Nakagawa M;Mizuno T;篠田晃
• 通讯作者: 篠田晃