Role of signal transduction pathway of Bcl-3 and IkBNA in the pathogenesis of psoriasis

Bcl-3和IkBNA信号转导通路在银屑病发病中的作用

• 批准号: 21390325
• 负责人: HASHIMOTO Koji
• 金额: $ 11.48万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390325/
• 关键词: 尋常性乾癬; シグナル伝達; 培養角化細胞; NFkB; Bcl-3; IkBNS; IkBNF; IkBNS欠損マウス; STAT3; Bc1-3

In order to clarify the role of NF-kB in the pathogenesis of psoriasis, we examined whether pathological change of psoriasis was induced in IkBNS deficient mice. We also clarified the function of Bcl-3 in cultured epidermal keratinocytes. Although the IkBNS deficient mice did not spontaneously generate psoriatic skin phenotype, the psoriasis pathological change was induced by the wound stimulus and the TPA treatment. IL-22-induced psoriasis-related genes were suppressed by the pretreatment of Bcl-3 suppression. On the other hand, overexpression of Bcl-3 induced psoriasis-related gene expression. Furthermore, Bcl-3 was strongly detected psoriatic skin. In conclusion, NFkB and Bcl-3 play important roles in the pathogenesis of psoriasis.

为了阐明NF-kB在银屑病发病机制中的作用，我们检测了IkBNS缺陷小鼠是否会诱导银屑病的病理变化。我们还阐明了 Bcl-3 在培养的表皮角质形成细胞中的功能。尽管IkBNS缺陷小鼠并未自发产生银屑病皮肤表型，但银屑病病理变化是由伤口刺激和TPA治疗诱导的。 Bcl-3 抑制的预处理可抑制 IL-22 诱导的银屑病相关基因。另一方面，Bcl-3的过度表达诱导银屑病相关基因的表达。此外，Bcl-3在银屑病皮肤中也被强烈检测到。总之，NFkB和Bcl-3在银屑病的发病机制中发挥着重要作用。

项目成果

Diagnosis and Treatment of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular Complications

• DOI: 10.1016/j.ophtha.2008.12.048
• 发表时间: 2009-04-01
• 期刊: OPHTHALMOLOGY
• 影响因子: 13.7
• 作者: Sotozono, Chie;Ueta, Mayumi;Kinoshita, Shigeru
• 通讯作者: Kinoshita, Shigeru

Successful treatment of severe pemphigus vulgaris with high-dose intravenous immunoglobulin

大剂量静脉注射免疫球蛋白成功治疗重症寻常型天疱疮

• 发表时间: 2010
• 作者: Shirakata Y;Ishikawa M;Murakami S;Hashimoto K
• 通讯作者: Hashimoto K

Living skin equivalents constructed using human amnions as a matrix

• DOI: 10.1016/j.jdermsci.2009.09.009
• 发表时间: 2009-12-01
• 期刊: JOURNAL OF DERMATOLOGICAL SCIENCE
• 影响因子: 4.6
• 作者: Yang, Lujun;Shirakata, Yuji;Hashimoto, Koji
• 通讯作者: Hashimoto, Koji

Pathogenic Anti-Desmoglein 3 mAbs Cloned from a Paraneoplastic Pemphigus Patient by Phage Display

• DOI: 10.1038/jid.2011.449
• 发表时间: 2012-04-01
• 期刊: JOURNAL OF INVESTIGATIVE DERMATOLOGY
• 影响因子: 6.5
• 作者: Saleh, Marwah A.;Ishii, Ken;Amagai, Masayuki
• 通讯作者: Amagai, Masayuki

Successful treatment of severe pemphigus vulgaris with high-dose intravenous immunoglobulin.

大剂量静脉注射免疫球蛋白成功治疗严重寻常型天疱疮。

• 发表时间: 2010
• 作者: Shirakata Y;Ishikawa M;Murakami S;Hashimoto K
• 通讯作者: Hashimoto K