Role of babesiacidal proteins in the vector tick and development of therapeutic agents against bebesiosis

巴贝西虫酸蛋白在媒介蜱中的作用和抗贝贝西虫病治疗剂的开发

• 批准号: 21380190
• 负责人: TSUJI Naotoshi
• 金额: $ 12.15万
• 依托单位: National Agriculture and Food Research Organization
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380190/
• 关键词: 獣医学; 感染症; 吸血性節足動物; マダニ; バベシア症; 殺バベシア原虫ペプチド; 中腸; 唾液腺

Several babesiacidal proteins associated with differentiation and proliferation of Babesia parasites were identified from the piroplamosis vector tick, Haemaphysalis longicornis. Peptides based on the secondary structure possessed lethal effect on the intra-erythrocytic stage of Babesia that cause animal babesiosis. Lethal-effects of these peptides were also detected against other animal protozoan disease including toxoplasmosis.

从piroplamisosis载体tick虫（Haemaphysalis longicornis）中鉴定出与贝贝西亚寄生虫分化和增殖相关的几种巴氏蛋白质蛋白。基于二级结构的肽对引起动物babesios的贝贝西亚的肉体内阶段具有致命作用。还针对包括弓形虫病在内的其他动物原生动物疾病检测到这些肽的致命作用。

项目成果

バベシア原虫感染フタトゲチマダニにおける卵巣内移行原虫の定量的検出

巴贝斯原虫感染蜱卵巢内转移原虫的定量检测

• 发表时间: 2009
• 作者: 八田岳士;辻尚利;三好猛晴;Abdul Alim;山地佳代子;Anisuzzaman;藤崎幸藏
• 通讯作者: 藤崎幸藏

Longistatin, a potent salivary-gland plasminogen activator from ixodid tick, is critical for blood pool development and successful blood-feeding by the ticks

长抑素是一种来自蜱蜱的有效唾液腺纤溶酶原激活剂，对于蜱虫的血池发育和成功吸血至关重要

• 发表时间: 2010
• 作者: Anisuzzaman;Islam Mkhyrul;Miyoshi Takeharu;Abdul M Alim;Hatta Takeshi;Yamaji Kayoko;Matsumoto Yasunobu;Fujisaki Kozo;Tsuji Naotoshi
• 通讯作者: Tsuji Naotoshi

RNA-Seq Analysis of Embryo of the tick Haemaphysalis longicornis

长角血蜱胚胎的 RNA 测序分析

• 发表时间: 2012
• 作者: 塚越太郎,大野耕一;他;八田岳士,松林誠,三好猛晴,イスラムカイルル,アリムアブドゥル,山地佳代子,藤崎幸蔵,辻尚利
• 通讯作者: 八田岳士,松林誠,三好猛晴,イスラムカイルル,アリムアブドゥル,山地佳代子,藤崎幸蔵,辻尚利

A novel chymotripsin inhibitor from the hard tick Haemaphysalis longicornis is involved in blood-feeding process

来自硬蜱 Haemaphysalis longicornis 的新型糜蛋白酶抑制剂参与血液喂养过程

• 发表时间: 2011
• 作者: M. Abdul Alim;Naotoshi Tsuji;Takeharu Miyoshi;M. Khyrul Islam;Takeshi Hatta;Kayoko Yamaji;Anisuzzaman;Kozo Fujisaki
• 通讯作者: Kozo Fujisaki

Tick longicin implicated in the arthropod transmission of Toxoplasma gondii

• DOI: 10.4172/2157-7579.1000112
• 发表时间: 2012-01-01
• 期刊: J Vet Sci Technol
• 作者: Tanaka, T.;Maeda, H.;Suzuki, H.
• 通讯作者: Suzuki, H.