Novel roles of adipocytes in the mammary gland development and breast cancer progression, and involvement of adipokines in the roles

脂肪细胞在乳腺发育和乳腺癌进展中的新作用，以及脂肪因子在这些作用中的参与

• 批准号: 21380177
• 负责人: KIMURA Kazuhiro
• 金额: $ 12.4万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380177/
• 关键词: 乳腺; 乳癌; 脂肪細胞; エストロゲン; プロラクチン; レプチン; HGF; NGF; 乳腺発達; プロゲステロン; STAT; 母性行動; ストレス; 脳機能; 肥満; 泌乳

The mammary gland develops in subcutaneous adipose tissue in the post natal period, and adipocytes function as a nursing cell for epithelial cells. With hypertrophy of adipocytes, ductal development of mammary gland in non-pregnant mice was impaired. Hypertrophy of adipocytes also delayed side-branch formation from the duct in the early phase of pregnancy, and acinar formation and its maturation in the mid-and late phase of pregnancy. Hypertrophy of adipocytes caused hyper-leptinemia, and leptin mimicked some effects by hypertrophy of adipocytes both in vivo and in vitro. Therefore, it was suggested that hypertrophy of adipocytes suppressed mammary gland development and leptin partly played a role in the suppression.

乳腺在出生后期在皮下脂肪组织中发育，脂肪细胞充当上皮细胞的护理细胞。伴有脂肪细胞的肥大，非妊娠小鼠的乳腺导管发育受损。脂肪细胞的肥大还延迟了妊娠早期的管道的侧分支形成，腺泡的形成及其在怀孕后期和后期的成熟。脂肪细胞肥大会引起高纤维素血症，瘦素模仿体内和体外脂肪细胞肥大的某些作用。因此，据建议，脂肪细胞肥大抑制乳腺发育，瘦素部分在抑制中起作用。

项目成果

Possible involvement of uncoupling protein 1 in appetite control by leptin

• DOI: 10.1258/ebm.2011.011143
• 发表时间: 2011-11-01
• 期刊: EXPERIMENTAL BIOLOGY AND MEDICINE
• 影响因子: 3.2
• 作者: Okamatsu-Ogura, Yuko;Nio-Kobayashi, Junko;Saito, Masayuki
• 通讯作者: Saito, Masayuki

Effects of retinoic acid on lipid accumulation in bovine and mouse adipocytes are inverted dependently on glucose concentration in the cultures

视黄酸对牛和小鼠脂肪细胞脂质积累的影响取决于培养物中的葡萄糖浓度

• 发表时间: 2009
• 作者: Abd El Daim Mabrouk;Mohamed Ahmed;岡松優子,上川昭博,寺尾晶,木村和弘
• 通讯作者: 岡松優子,上川昭博,寺尾晶,木村和弘

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

• DOI: 10.1016/j.peptides.2012.02.012
• 发表时间: 2012-04
• 期刊: Peptides
• 影响因子: 3
• 作者: K. Shimada;Yuta Ohno;Y. Okamatsu-Ogura;Masahiro Suzuki;A. Kamikawa;A. Terao;K. Kimura

肥満の成因・病態とビタミンAによる脂肪量の調節

肥胖的原因和病理以及维生素 A 对脂肪量的调节

• 发表时间: 2010
• 作者: Adachi K;Hattori M;Kato H;Inai M;Tsukamoto M;Handharyani E;Taira E;Tsukamoto Y;木村和弘
• 通讯作者: 木村和弘

In:Sima AAF (ed) Diabetes and C-Peptide:Scientific and Clinical Aspects. Contemporary Diabetes

见：Sima AAF（编辑）糖尿病和 C 肽：科学和临床方面。

• 发表时间: 2012
• 作者: Kimura;K. and Kamikawa;A
• 通讯作者: A