Gene networks underlying development of the Drosophila central nervous system

果蝇中枢神经系统发育的基因网络

• 批准号: 21370096
• 负责人: TABATA Tetsuya
• 金额: $ 12.31万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21370096/
• 关键词: ショウジョウバエ; 視覚中枢; 嗅覚中枢; キノコ体; EGF; Notch; PCP; アクチン; 軸索投射; 軸索伸長; マイクロアレイ; 視覚系神経; 発生分化; 軸索形成; アクチン重合; sickie; Wnt5; ラミナ; メダラ; マッシュルームボディ; EGFR

The molecular mechanisms underlying development of Drosophila lamina and medulla optic ganglia have been studied. We have identified(1) cell surface molecules that are required for recognition between lamina precursor cells and retinal axons,(2) coordinated sequential action of the EGFR and Notch signaling pathways that induce medulla neuroblasts formation in a precisely ordered manner. We have also identified genes involved in planer cell polarity and actin remodeling as important players that regulate axon elongation and guidance of the mushroom body, the center of the olfactory memory formation.

果蝇椎板和髓质视神经节发育的分子机制已被研究。我们已经确定了（1）层板前体细胞和视网膜轴突之间识别所需的细胞表面分子，（2）EGFR 和 Notch 信号通路的协调顺序作用，以精确有序的方式诱导髓质神经母细胞形成。我们还发现参与平面细胞极性和肌动蛋白重塑的基因是调节轴突伸长和蘑菇体引导的重要参与者，蘑菇体是嗅觉记忆形成的中心。

项目成果

RNA interference screening for genes involved in the development of Drosophila mushroom body.

RNA干扰筛选参与果蝇蘑菇体发育的基因。

• 发表时间: 2010
• 作者: Yohei Nitta;Kazumichi Shimizu;Maki Ohtsubo;Tetsuya Tabata
• 通讯作者: Tetsuya Tabata

The Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe

Fat/Hippo 通路调节果蝇视叶神经分化信号的进展

• 发表时间: 2011
• 期刊: Growth Diff
• 作者: Kawamori;H.;Tai;M.;Sato;M.;Yasugi;T.;Tabata;T.
• 通讯作者: T.

Cellular and molecular mechanisms underlying neural formation in Drosophila visual system development

果蝇视觉系统发育中神经形成的细胞和分子机制

• 发表时间: 2010
• 作者: Tabata;T.
• 通讯作者: T.

Roles of Wnt Signal in Development of Drosophila Mushroom Body.

Wnt 信号在果蝇蘑菇体发育中的作用。

• 发表时间: 2010
• 作者: Kazumichi Shimizu;Makoto Sato;Tetsuya Tabata
• 通讯作者: Tetsuya Tabata

Recognition of pre-and postsynaptic neurons via nephrin/NEPHl homologs is a basis for the formation of the Drosophila retinotopic map

通过去氧肾上腺素/NEPH1同源物识别突触前和突触后神经元是形成果蝇视网膜专题图的基础

• 发表时间: 2010
• 期刊: Development
• 影响因子: 4.6
• 作者: Sugie;A.;Umetsu;D.;Yasugi;T.;Fischbach;K.-F. and Tabata. T.
• 通讯作者: K.-F. and Tabata. T.